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The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all? (2020)
Journal Article

Pet ownership is common. Growing evidence suggests children form deep emotional attachments to their pets. Yet, little is known about children’s emotional reactions to a pet’s death. The goal of this study was to describe the relationship between exp... Read More about The mental health effects of pet death during childhood: Is it better to have loved and lost than never to have loved at all?.

Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles (2019)
Journal Article

BACKGROUND: It is not known whether segmentation of an in vitro fertilisation (IVF) cycle, with freezing of all embryos prior to transfer, increases the chance of a live birth after all embryos are transferred. METHODS: In a prospective study of UK H... Read More about Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles.

Parametric and non-parametric tests for the comparison of two samples which both include paired and unpaired observations (2019)
Journal Article

Samples that include both independent and paired observations cause a dilemma for researchers that covers the full breadth of empirical research. Parametric approaches for the comparison of two samples using all available observations are considered,... Read More about Parametric and non-parametric tests for the comparison of two samples which both include paired and unpaired observations.

Young carers in England: Findings from the 2018 BBC survey on the prevalence and nature of caring among young people (2019)
Journal Article

© 2019 John Wiley & Sons Ltd Background: Many young people are involved in caring for parents, siblings, or other relatives who have an illness or disability. The aim of this study was to estimate the prevalence of caring by young people in England... Read More about Young carers in England: Findings from the 2018 BBC survey on the prevalence and nature of caring among young people.

Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study (2019)
Journal Article

Background: Exposure to "early life" adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposu... Read More about Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study.

Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures (2018)
Journal Article

Abstract: Background: Glioblastomas account for 90% of all adult brain tumours. Patient survival remains low because treatments are ineffective against this lethal disease. Understanding the genes and pathways altered in subtypes is necessary for th... Read More about Genomic profiling of IDH-wildtype and IDH-mutant initial and matched recurrent glioblastomas reveals clinically actionable mutations (e.g. BRCA1/2) and resistance signatures.

Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial (2018)
Journal Article

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Thyroid eye disease (TED) is a potentially sight-threatening and cosmetically disfiguring condition arising in 25–50% of patients with Graves’ hyperthyroidism. CIRTED is the fir... Read More about Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial.

Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS) (2018)
Journal Article

© 2018 The Author(s). Background: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in... Read More about Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS).

Time to Initial Debridement and wound Excision (TIDE) in severe open tibial fractures and related clinical outcome: A multi-centre study (2018)
Journal Article

© 2018 Elsevier Ltd Background: Recent national (NICE) guidelines in England recommend that initial debridement and wound excision of open tibial fractures take place within 12 h of the time of injury, a change from the previous target of 24 h. This... Read More about Time to Initial Debridement and wound Excision (TIDE) in severe open tibial fractures and related clinical outcome: A multi-centre study.

Preschool children’s communication, motor and social development: Parents’ and educators’ concerns (2018)
Journal Article

© 2017, © 2017 The Speech Pathology Association of Australia Limited. Purpose: During early childhood, it is important to identify which children require intervention before they face the increased demands of school. This study aimed to: (1) compare... Read More about Preschool children’s communication, motor and social development: Parents’ and educators’ concerns.