Preface
(2014)
Journal Article
Outputs (1718)
Introduction & Aims: The distribution of the BCAT proteins has been extensively mapped in rodent models, and metabolic studies have established that BCAT transamination in the rodent brain is responsible for 30% of de novo glutamate synthesis. Howeve... Read More about The investigation of the hBCAT proteins in control and diseased human brains: Implications for glutamate toxicity in Alzheimer’s disease.
Hydrogen sulfide and cell signaling: Team player or referee? (2014)
Journal Article
Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter, and along with other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is thought to be a key signalling molecule. Enzymes which generate H2S,... Read More about Hydrogen sulfide and cell signaling: Team player or referee?.
Atmin is a transcriptional regulator of both lung morphogenesis and ciliogenesis (2014)
Journal Article
© 2014. Initially identified in DNA damage repair, ATM-interactor (ATMIN) further functions as a transcriptional regulator of lung morphogenesis. Here we analyse three mouse mutants, Atmingpg6/gpg6, AtminH210Q/H210Q and Dynll1GT/GT, revealing how ATM... Read More about Atmin is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013 (2014)
Journal Article
Aims A biomarker is an entity that measures a normal or pathological process, or the response to an intervention. A biomarker must measure exclusively and be sufficiently sensitive to the process of interest. Alternatively, a biomarker may give clues... Read More about What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013.
Introduction Triple negative breast cancers are defined by their lack of expression of HER, oestrogen receptors and progesterone receptors. They account for around 10-24% of cases. To define a cancer by the biomarkers it does not express is unsati... Read More about An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo.
Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662 (2014)
Journal Article
Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote t... Read More about Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662.
Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis (2014)
Journal Article
It has been suggested that mixing alcohol with energy drinks or other caffeinated beverages may alter the awareness of (or 'mask') intoxication. The proposed reduction in subjective intoxication may have serious consequences by increasing the likelih... Read More about Effects of mixing alcohol with caffeinated beverages on subjective intoxication: A systematic review and meta-analysis.
Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients (2014)
Journal Article
© Springer-Verlag Berlin Heidelberg 2014. Bioluminescent bacterial biosensors can be used in a rapid in vitro assay to predict sensitivity to commonly used chemotherapy drugs in acute myeloid leukemia (AML). The nucleoside analog cytarabine (ara-C) i... Read More about Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.
A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements (2014)
Journal Article
High density lipoprotein cholesterol (HDL-C) is a modifiable risk factor in cardiovascular disease and devices suitable for its determination at the point of care are critical to the future management of hypercholesterolaemia. An electrochemical bios... Read More about A biosensor for the determination of high density lipoprotein cholesterol employing combined surfactant-derived selectivity and sensitivity enhancements.
In this study, we investigate the potential for oral Lactobacilli (LB) to afford innate protection against nasopharyngeal coloniser Neisseria meningitidis serogroup B (NmB), which causes the bulk of UK meningococcal disease. Oral isolates of L. plant... Read More about Oral Lactobacillus plantarum NCIMB 8825 inhibits adhesion, invasion and metabolism of Neisseria meningitidis serogroup B and affords anti-inflammatory and cytotoxic protection to nasopharyngeal epithelial cells.
Drop-coated titanium dioxide memristors (2013)
Journal Article
The fabrication of memristors by drop-coating sol-gel Ti(OH)4 solution onto either aluminium foil or sputter-coated aluminium on plastic is presented. The gel layer is thick, 37 μm, but both devices exhibit good memristance I-V profiles. The drop coa... Read More about Drop-coated titanium dioxide memristors.
Nitric oxide signaling in plants (2014)
Journal Article
Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations (2014)
Journal Article
Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are... Read More about Electrochemical detection of benzodiazepines, following liquid chromatography, for applications in pharmaceutical, biomedical and forensic investigations.
Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy (2013)
Journal Article
Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy. 92 An evaluative assay to determine resistance/sensitivity to ara- C prior... Read More about Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy.
Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment (2013)
Journal Article
The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and... Read More about Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment.
Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival (2014)
Thesis
Introduction: Diabetes affects more than 346 million individuals worldwide. Some 90% of diabetics have type 2 diabetes mellitus, which is frequently associated with obesity and hyperlipidemia as well as hyperglycaemia. There is ample evidence that... Read More about Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival.
Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography (2013)
Journal Article
The kinetic performance of a bare silica and C18 phase prepared from the same sub-2. μm and 3.5. μm base materials were compared in the HILIC and RP mode using both charged and neutral solutes. The HILIC column was characterised using the neutral sol... Read More about Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography.
Introduction (2014)
Book Chapter
Nano-scale materials are proving attractive for a new generation of devices, due to their unique properties. They are used to create fast-responding sensors with good sensitivity and selection for the detection of chemical species and biological agen... Read More about Introduction.
Introduction: The hBCAT proteins have a unique redox active CXXC motif which governs its transamination activity. Recent studies have identified that specific neuronal proteins with either redox activity or functions in cell signalling form interac... Read More about The role of phosphorylation and redox regulation of the brain specific hBCAT proteins in vitro and in neuronal cells.