Outputs (1248)

Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia (2019)
Journal Article

© 2019 Cytarabine remains the backbone of therapy in acute myeloid leukemia (AML). The ability to assess intracellular cytarabine triphosphate (ara-CTP) levels in patients receiving cytarabine represents a major goal in the prediction of treatment re... Read More about Intracellular cytarabine triphosphate in circulating blasts post-treatment predicts remission status in patients with acute myeloid leukemia.

Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles (2019)
Journal Article

© 2019 Elsevier B.V. Antibiotic resistance is set to be an unprecedented threat to modern medicine. ‘Sniffing’ bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal deso... Read More about Sniffing out resistance – Rapid identification of urinary tract infection-causing bacteria and their antibiotic susceptibility using volatile metabolite profiles.

Wnt signaling is a major determinant of neuroblastoma cell lineages (2019)
Journal Article

© 2019 Szemes, Greenhough and Malik. The neural crest (NC), which has been referred to as the fourth germ layer, comprises a multipotent cell population which will specify diverse cells and tissues, including craniofacial cartilage and bones, melanoc... Read More about Wnt signaling is a major determinant of neuroblastoma cell lineages.

Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus (2015)
Journal Article

© 2015 Skindersoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are... Read More about Dual Action of lysophosphatidate- functionalised titanium: Interactions with human (MG63) osteoblasts and methicillin resistant staphylococcus aureus.

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis (2015)
Journal Article

©2015. To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells. This... Read More about Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis.

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2017)
Journal Article

© 2017 Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, the... Read More about Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism.

Development of a simple, low cost chronoamperometric assay for fructose based on a commercial graphite-nanoparticle modified screen-printed carbon electrode (2017)
Journal Article

© 2017 Elsevier Ltd This paper describes the development of a simple, low cost chronoamperometric assay, for the measurement of fructose, using a graphite-nanoparticle modified screen-printed electrode (SPCE-G-COOH). Cyclic voltammetry showed that th... Read More about Development of a simple, low cost chronoamperometric assay for fructose based on a commercial graphite-nanoparticle modified screen-printed carbon electrode.

Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants (2017)
Journal Article

© 2017, The Author(s). Preterm delivery is associated with neurodevelopmental impairment caused by environmental and genetic factors. Dysfunction of the excitatory amino acid transporter 2 (EAAT2) and the resultant impaired glutamate uptake can lead... Read More about Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants.

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity (2017)
Journal Article

© The Author(s) named above 2018. Background:LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5 + cells are known to exist outside... Read More about LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.

Targeting splicing in prostate cancer (2018)
Journal Article

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Over 95% of human genes are alternatively spliced, expressing splice isoforms that often exhibit antagonistic functions. We describe genes whose alternative splicing has been linked to prostat... Read More about Targeting splicing in prostate cancer.

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells (2018)
Journal Article

© 2018 The Author(s). Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer as... Read More about Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

Isolation and characterisation of bacteriophages for use against biofilms of Pseudomonas aeruginosa clinical isolates (2018)
Presentation / Conference Contribution

Pseudomonas aeruginosa is a World Health Organization priority 1, ESKAPE pathogen that is capable of causing a wide spectrum of nosocomial and community-acquired infections. It employs a wide range of antibiotic resistance mechanisms and is often dif... Read More about Isolation and characterisation of bacteriophages for use against biofilms of Pseudomonas aeruginosa clinical isolates.

Characterisation of a dual species perfusion biofilm model (2018)
Presentation / Conference Contribution

An estimated 65–80% of human infections are biofilm-related. As the biofilm mode of growth significantly contributes to bacterial tolerance of antimicrobial treatment, this has important ramifications for patient morbidity and associated healthcare c... Read More about Characterisation of a dual species perfusion biofilm model.

Reviewing the evidence on mitigation strategies for bats in buildings informing best-practice for policy makers and practitioners (2018)
Report

This study aimed to provide evidence to planners, developers and ecological practitioners on the efficacy of bat roost mitigation and compensation to help them ensure that mitigation approaches are evidence-based and beneficial for bats. Primary obj... Read More about Reviewing the evidence on mitigation strategies for bats in buildings informing best-practice for policy makers and practitioners.

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1 (2018)
Journal Article

© 2018 The Author(s). Differential trafficking of AMPA receptors (AMPARs) to and from the postsynaptic membrane is a key determinant of the strength of excitatory neurotransmission, and is thought to underlie learning and memory. The transcription fa... Read More about MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Optimized delivery of siRNA into 3D tumor spheroid cultures in situ (2018)
Journal Article

© 2018 The Author(s). 3D tissue culture provides a physiologically relevant and genetically tractable system for studying normal and malignant human tissues. Despite this, gene-silencing studies using siRNA has proved difficult. In this study, we hav... Read More about Optimized delivery of siRNA into 3D tumor spheroid cultures in situ.

Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2018)
Journal Article

Growth and maintenance of cells is partly controlled by the production and perception of a range of small relatively reactive molecules, including reactive oxygen species, nitric oxide and hydrogen sulfide: what may be dubbed reactive signaling molec... Read More about Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Quantifying the attractiveness of broad-spectrum street lights to aerial nocturnal insects (2017)
Journal Article

© 2017 The Authors. Journal of Applied Ecology Published by John Wiley & Sons Ltd on behalf of British Ecological Society Sodium street lights, dominated by long wavelengths of light, are being replaced by broad-spectrum, white lights globally, in... Read More about Quantifying the attractiveness of broad-spectrum street lights to aerial nocturnal insects.

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma (2018)
Journal Article

© 2018 Neuroblastoma is one of the commonest and deadliest solid tumours of childhood, and is thought to result from disrupted differentiation of the developing sympathoadrenergic lineage of the neural crest. Neuroblastoma exhibits intra- and intertu... Read More about Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma.

Molecular evidence of Cacao swollen shoot virus acquisition and retention by Planococcus citri (Risso) and Pseudococcus longispinus (Targioni-Tozzetti) and Pseudococcus viburni (Signoret) Mealybugs (Hemiptera: Pseudococcidae) (2018)
Journal Article

Cacao swollen shoot virus (CSSV) remains a significant viral pathogen endemic in West African cacao-growing countries. Eradication of affected trees (complete removal) and resistance breeding in existing cacao (Theobroma cacao L.) germplasm have not... Read More about Molecular evidence of Cacao swollen shoot virus acquisition and retention by Planococcus citri (Risso) and Pseudococcus longispinus (Targioni-Tozzetti) and Pseudococcus viburni (Signoret) Mealybugs (Hemiptera: Pseudococcidae).