Outputs (638)

The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis (2015)
Journal Article

© 2015 by the authors; licensee MDPI, Basel, Switzerland. The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells betwee... Read More about The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis.

Theoretical considerations for thresholds in chemical carcinogenesis (2015)
Journal Article

© 2015 Elsevier B.V. There is increasing evidence for non-linear relationships for gene mutations, chromosomal aberrations and even tumor incidences in response to low doses of genotoxic carcinogens. To attain the biological relevance of such non-lin... Read More about Theoretical considerations for thresholds in chemical carcinogenesis.

DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis (2015)
Journal Article

© The Author 2015. Published by Oxford University Press. All rights reserved. Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O6-methylguanine (O6-M... Read More about DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

The cytosolic and mitochondrial branched-chain aminotransferase (2015)
Book Chapter

Key Points • The branched chain aminotransferases (BCAT) are PLP dependent proteins which catalyze the transfer of an amino group from the donor amino acid to α-ketoglutarate, forming glutamate and the respective keto acids. • Structurally the BC... Read More about The cytosolic and mitochondrial branched-chain aminotransferase.

Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways (2015)
Book Chapter

Hydrogen sulfide (H2S) is now considered to be a signalling molecule in a range of organisms. In animals and plants there are characterised mechanisms for its generation and removal suggesting that it can be made and have an effect when required. In... Read More about Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways.

The design, development and application of novel, screen-printed amperometric glutamate biosensors (2015)
Thesis

The aim of the studies presented in this thesis was to develop a screen-printed electrochemical biosensor for the measurement of glutamate and to apply this device to the determination of the analyte in food, serum and toxicity studies. Chapter 1... Read More about The design, development and application of novel, screen-printed amperometric glutamate biosensors.

A novel biosensor for prediction of global hypomethylation by decitabine and azacytadine in leukaemic cells (2015)
Journal Article

Decitabine (DAC) and azacytidine (AZA) are cytidine ana- logues and hypomethylating agents used in the manage- ment of patients with myelodysplastic syndrome (MDS), where the main goal is to prevent transformation to acute myeloid leukaemia (AML), wh... Read More about A novel biosensor for prediction of global hypomethylation by decitabine and azacytadine in leukaemic cells.

The stromal cell line HS-5 is an alternative mesenchymal stem cell source for the development of a 3D bone marrow model (2015)
Journal Article

Developing a novel three-dimensional (3D) in vitro model of the bone marrow microenvironment using bone mar- row mesenchymal stem cells (BM-MSCs) in commercial matrices involves a series of distinct processes. This starts with selecting an appropriat... Read More about The stromal cell line HS-5 is an alternative mesenchymal stem cell source for the development of a 3D bone marrow model.

Determination of the appropriate gene for real-time PCR analysis of the immotalized stromal cell line HS-5 in 2D and 3D culture following melphalan exposure (2015)
Journal Article

Although gene expression analysis using real-time quan- titative reverse transcription-polymerase chain reaction (RT-qPCR) is an accurate method to evaluate cell activi- ties and phenotypes, the reliability of the analysis depends on the selection of... Read More about Determination of the appropriate gene for real-time PCR analysis of the immotalized stromal cell line HS-5 in 2D and 3D culture following melphalan exposure.

Bone marrow and myeloma cellular communication protects from genotoxicity in a drug-specific manner (2015)
Journal Article

Multiple myeloma (MM) is an incurable haematological malignancy with most patients eventually developing ad- vanced, relapsing disease and drug resistance (1,2). This may result from protection by BM mesenchymal cells (BM— MSC) interacting with MM ce... Read More about Bone marrow and myeloma cellular communication protects from genotoxicity in a drug-specific manner.

Inter-Taxa differences in iodine uptake by plants: Implications for food quality and contamination (2015)
Journal Article

© 2015 by the authors. Although iodine is not essential for plants, they take it up readily and, in foodchains, are significant sources of iodine for organisms with an essential requirement for it. During several nuclear accidents radioiodine has bee... Read More about Inter-Taxa differences in iodine uptake by plants: Implications for food quality and contamination.

The Molecular Biology of RNA (2015)
Book

Determination of Malachite Green in Aquaculture Water by Adsorptive Stripping Voltammetry (2016)
Journal Article

© 2016, Copyright © Taylor & Francis Group, LLC. An adsorptive stripping voltammetric method for the determination of malachite green in aquaculture water has been developed. Initial studies were made using the cyclic voltammetry of malachite green... Read More about Determination of Malachite Green in Aquaculture Water by Adsorptive Stripping Voltammetry.

Design and application of liquid chromatography dual electrode detection (2015)
Book Chapter

Liquid chromatography with electrochemical detection has been shown to be both highly sensitive and selective. Initially electrochemical detection in this approach has utilised single electrode based electrochemical detector systems, where the compou... Read More about Design and application of liquid chromatography dual electrode detection.

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma (2015)
Journal Article

LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neurobla... Read More about LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma.

Opportunities for improving the foraging potential of urban waterways for bats (2015)
Journal Article

© 2015 Elsevier B.V.. The rapid rate of urbanisation over the past century has occurred over a relatively small proportion of the earth's surface, yet it has had considerable ecological impact at a global scale. Urban waterways have historically been... Read More about Opportunities for improving the foraging potential of urban waterways for bats.

Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes (2015)
Journal Article

© 2015 Elsevier B.V. Abstract Here we describe the construction and optimization of a cholesterol biosensor based on screen-printed electrodes (SPEs) modified with inkjet-printed Prussian blue nanoparticles (PBNPs). The deposition of PBNPs using inkj... Read More about Cholesterol biosensor based on inkjet-printed Prussian blue nanoparticle-modified screen-printed electrodes.

SUMOylation of Syntaxin1A regulates presynaptic endocytosis (2015)
Journal Article

Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis eve... Read More about SUMOylation of Syntaxin1A regulates presynaptic endocytosis.

Environmental Plant Physiology (2015)
Book

Environmental Plant Physiology focuses on the physiology of plant-environment interactions, revealing plants as the key terrestrial intersection of the biosphere, atmosphere, hydrosphere and geosphere. It provides a contemporary understanding of the... Read More about Environmental Plant Physiology.

DNA damage and the balance between survival and death in cancer biology (2016)
Journal Article

© 2016 Macmillan Publishers Limited. DNA is vulnerable to damage resulting from endogenous metabolites, environmental and dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics. Cells respond to DNA damage by activating... Read More about DNA damage and the balance between survival and death in cancer biology.