Skip to main content

Research Repository

See what's under the surface

Design and application of liquid chromatography dual electrode detection

Honeychurch, Kevin C

Authors



Contributors

Craig Banks
Editor

Roger Mortimer
Editor

Steven Mcintosh
Editor

Abstract

Liquid chromatography with electrochemical detection has been shown to be both highly sensitive and selective. Initially electrochemical detection in this approach has utilised single electrode based electrochemical detector systems, where the compounds eluting form the chromatographic are detected by direct oxidation or reduction to generate the analytical signal. This has been shown to work well for a range of compounds. However, a number of analytes require high applied potentials for their oxidation or reduction. This can lead to problems in decreased signal-to-noise ratios, increased interference problems and large background currents. Several methods to overcome these issues have been investigated, such as derivatisation which can add further complexation to method and the possible introduction of contaminates that can interfere. An alternative approach is the application of dual electrode detection which is discussed in detail in this review.

Publication Date Nov 19, 2015
Peer Reviewed Peer Reviewed
Volume 13
Pages 1-20
Series Title Specialist Periodical Reports
Book Title Specialist Periodical Reports
ISBN 9781849739801
Institution Citation Honeychurch, K. C. (2015). Design and application of liquid chromatography dual electrode detection. In C. Banks, R. Mortimer, & S. Mcintosh (Eds.), Specialist Periodical Reports, 1-20. Royal Society of Chemistry. https://doi.org/10.1039/9781782620273
DOI https://doi.org/10.1039/9781782620273
Keywords liquid chromatography, dual electrode detection, drugs, environmental pollutants, amperometry, coulometry
Publisher URL http://dx.doi.org/10.1039/9781782620273

Files







You might also like



Downloadable Citations