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Design and application of liquid chromatography dual electrode detection

Honeychurch, Kevin C

Design and application of liquid chromatography dual electrode detection Thumbnail



Craig Banks

Roger Mortimer

Steven Mcintosh


Liquid chromatography with electrochemical detection has been shown to be both highly sensitive and selective. Initially electrochemical detection in this approach has utilised single electrode based electrochemical detector systems, where the compounds eluting form the chromatographic are detected by direct oxidation or reduction to generate the analytical signal. This has been shown to work well for a range of compounds. However, a number of analytes require high applied potentials for their oxidation or reduction. This can lead to problems in decreased signal-to-noise ratios, increased interference problems and large background currents. Several methods to overcome these issues have been investigated, such as derivatisation which can add further complexation to method and the possible introduction of contaminates that can interfere. An alternative approach is the application of dual electrode detection which is discussed in detail in this review.


Honeychurch, K. C. (2015). Design and application of liquid chromatography dual electrode detection. In C. Banks, R. Mortimer, & S. Mcintosh (Eds.), Specialist Periodical Reports (1-20). Cambridge: Royal Society of Chemistry.

Publication Date Nov 19, 2015
Deposit Date Apr 23, 2018
Publicly Available Date Apr 30, 2018
Peer Reviewed Peer Reviewed
Volume 13
Pages 1-20
Series Title Specialist Periodical Reports
Book Title Specialist Periodical Reports
ISBN 9781849739801
Keywords liquid chromatography, dual electrode detection, drugs, environmental pollutants, amperometry, coulometry
Public URL
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