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The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis

Qualtrough, David; Flemban, Arwa

Authors

David Qualtrough David.Qualtrough@uwe.ac.uk
Senior Lecturer in Healthcare Science - Cellular

Arwa Flemban arwa2.flemban@live.uwe.ac.uk



Abstract

© 2015 by the authors; licensee MDPI, Basel, Switzerland. The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells between these two cell types remains poorly understood. This relationship becomes of greater importance when studying the subtypes of epithelial breast carcinoma, which are categorized according to their expression of luminal or basal markers. The epithelial mesenchymal transition (EMT) is a pivotal event in tumor invasion. It is important to understand mechanisms that regulate this process, which bears relation to the normal dynamic of epithelial/basal phenotype regulation in the mammary gland. Understanding this process could provide answers for the regulation of EMT in breast cancer, and thereby identify potential targets for therapy. Evidence points towards a role for hedgehog signaling in breast tissue homeostasis and also in mammary neoplasia. This review examines our current understanding of role of the hedgehog-signaling (Hh) pathway in breast epithelial cells both during breast development and homeostasis and to assess the potential misappropriation of Hh signals in breast neoplasia, cancer stem cells and tumor metastasis via EMT.

Journal Article Type Review
Publication Date Sep 16, 2015
Journal Cancers
Electronic ISSN 2072-6694
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 7
Issue 3
Pages 1863-1884
APA6 Citation Qualtrough, D., & Flemban, A. (2015). The potential role of hedgehog signaling in the luminal/basal phenotype of breast epithelia and in breast cancer invasion and metastasis. Cancers, 7(3), 1863-1884. https://doi.org/10.3390/cancers7030866
DOI https://doi.org/10.3390/cancers7030866
Keywords breast cancer, hedgehog signaling, metastasis, luminal breast cancer, basal-like breast cancer, epithelial mesenchymal transition
Publisher URL http://dx.doi.org/10.3390/cancers7030866

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