David Qualtrough David.Qualtrough@uwe.ac.uk
Senior Lecturer in Healthcare Science - Cellular
The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro
Qualtrough, D.; Singh, K.; Banu, N.; Paraskeva, C.; Pignatelli, M.
Authors
K. Singh
N. Banu
C. Paraskeva
M. Pignatelli
Abstract
Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours. © 2009 Cancer Research UK.
Journal Article Type | Article |
---|---|
Publication Date | Sep 9, 2009 |
Journal | British Journal of Cancer |
Print ISSN | 0007-0920 |
Electronic ISSN | 1532-1827 |
Publisher | Springer Nature [academic journals on nature.com] |
Peer Reviewed | Peer Reviewed |
Volume | 101 |
Issue | 7 |
Pages | 1124-1129 |
DOI | https://doi.org/10.1038/sj.bjc.6605286 |
Keywords | colon, adenoma, fascin, migration |
Public URL | https://uwe-repository.worktribe.com/output/994020 |
Publisher URL | http://dx.doi.org/10.1038/sj.bjc.6605286 |
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