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The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

Qualtrough, D.; Singh, K.; Banu, N.; Paraskeva, C.; Pignatelli, M.

Authors

David Qualtrough David.Qualtrough@uwe.ac.uk
Senior Lecturer in Healthcare Science - Cellular

K. Singh

N. Banu

C. Paraskeva

M. Pignatelli



Abstract

Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours. © 2009 Cancer Research UK.

Journal Article Type Article
Publication Date Sep 9, 2009
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Springer Nature [academic journals on nature.com]
Peer Reviewed Peer Reviewed
Volume 101
Issue 7
Pages 1124-1129
DOI https://doi.org/10.1038/sj.bjc.6605286
Keywords colon, adenoma, fascin, migration
Public URL https://uwe-repository.worktribe.com/output/994020
Publisher URL http://dx.doi.org/10.1038/sj.bjc.6605286