The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

Qualtrough, D.; Singh, K.; Banu, N.; Paraskeva, C.; Pignatelli, M.

Abstract

Background: Fascin is overexpressed in many cancers, including colorectal, but its role in the malignant transformation of benign colorectal adenomas is unclear. Methods: Immunohistochemical analysis of fascin expression was carried out in resected human colorectal adenoma specimens. The effects of forced overexpression of fascin on adenoma cell motility were also analysed. Results: We show fascin overexpression in adenomas increasing with tumour size, histological type, and degree of dysplasia and increased cell motility in adenoma cell lines following fascin transfection. Conclusion: These data suggest an important role for fascin in the malignant progression of colorectal tumours. © 2009 Cancer Research UK.

• Journal Article Type: Article
• Publication Date: Sep 9, 2009
• Journal: British Journal of Cancer
• Print ISSN: 0007-0920
• Electronic ISSN: 1532-1827
• Publisher: Springer Nature [academic journals on nature.com]
• Peer Reviewed: Peer Reviewed
• Volume: 101
• Issue: 7
• Pages: 1124-1129
• DOI: https://doi.org/10.1038/sj.bjc.6605286
• Keywords: colon, adenoma, fascin, migration
• Public URL: https://uwe-repository.worktribe.com/output/994020
• Publisher URL: http://dx.doi.org/10.1038/sj.bjc.6605286