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Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort (2023)
Journal Article

Background: Childhood adversity is a potent determinant of health across development and is associated with altered DNA methylation signatures, which might be more common in children exposed during sensitive periods in development. However, it remain... Read More about Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort.

Early intravenous Beta-Blockade with esmolol in adults with severe Traumatic Brain Injury (EBB-TBI): A phase 2a intervention design study (2023)
Journal Article


Background
Targeted beta-blockade after severe traumatic brain injury may reduce secondary brain injury by attenuating the sympathoadrenal response. The potential role and optimal dose for esmolol, a selective, short-acting, titratable beta-1 beta... Read More about Early intravenous Beta-Blockade with esmolol in adults with severe Traumatic Brain Injury (EBB-TBI): A phase 2a intervention design study.

Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study (2023)
Journal Article

Traumatic brain injury is a leading cause of death and disability worldwide. Interventions that mitigate secondary brain injury have the potential to improve outcomes for patients and reduce the impact on communities and society. Increased circulatin... Read More about Early intravenous beta-blockade with esmolol in adults with severe traumatic brain injury (EBB-TBI): Protocol for a phase 2a intervention design study.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients (2023)
Journal Article

Background: The overall survival of IDH-wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to inform more precise disease stratification. Previous studies have identified insulin-like... Read More about Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.

Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs (2023)
Journal Article

Abstract

Background
Understanding the natural history of developmental speech and language impairments can support the selection of children whose difficulties are persistent rather than transitory. It can also provide information against which... Read More about Outcomes from a community speech and language therapy service treatment waiting list: The natural history of 525 children with identified speech and language needs.

The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol (2023)
Journal Article

Obesity is considered one of the biggest health problems of the 21st century, becoming a worldwide epidemic, leading to the development of many diseases and increasing the risk of premature death. The first step in reducing body weight is a calorie-r... Read More about The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol.

The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial (2023)
Journal Article

INTRODUCTION: Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease with a poor prognosis. Treatment approaches focus on symptom relief and optimising... Read More about The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial.

NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model (2023)
Journal Article

Background and Purpose: Wnt binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts... Read More about NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model.

Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort (2023)
Journal Article

Background: Women considering immediate breast reconstruction require high-quality information about the likely need for secondary reconstruction and the long-term risk of revisional surgery to make fully informed decisions about different reconstruc... Read More about Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort.

Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration (2023)
Journal Article

Introduction: Hospitalisations relating to acute respiratory deteriorations (ARD) in Interstitial Lung Disease (ILD) have poor outcomes. Factors predicting adverse outcomes are not fully understood and data addressing the use of illness severity scor... Read More about Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration.

Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions (2023)
Journal Article

Students may arrive at an incorrect answer when answering a mathematical question due to several reasons, such as random errors, calculation errors or misreading the question. Such errors are sometimes referred to as Common Student Errors (CSEs). Thi... Read More about Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions.

Review of the partially overlapping samples framework: Paired observations and independent observations in two samples (2022)
Journal Article

A frequently asked question in quantitative research is how to compare two samples that include some combination of paired observations and unpaired observations. In our publications and R package, we refer to the scenario as ‘partially overlapping... Read More about Review of the partially overlapping samples framework: Paired observations and independent observations in two samples.

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins (2022)
Journal Article

The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom... Read More about Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.

BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam (2022)
Journal Article

Objective: Via measures of efficacy, tolerability, and safety, this open-label, single-center study assessed the overall effectiveness of Brivaracetam (BRV) for the treatment of epilepsy in the context of ‘real-world’ clinical practice. Methods: Unse... Read More about BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam.

Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children (2022)
Journal Article

Background: Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when bes... Read More about Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children.

Gathering and compiling mathematical common student errors in e-assessment questions with taxonomical classification (2022)
Journal Article

This article gives an overview of the interactive book called ‘Collection of Taxonomically Classified Mathematical Common Student Errors in e-Assessments (CSE Book)’ which has been produced as a result of the Common Student Errors Project (CSE Projec... Read More about Gathering and compiling mathematical common student errors in e-assessment questions with taxonomical classification.