Outputs (124)

Editorial: Improving autism spectrum disorder diagnosis using machine learning techniques (2024)
Journal Article

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social communication, repetitive behaviors, and restricted interests (American Psychiatric Association, 2013). Early and accurate diagnosis is cri... Read More about Editorial: Improving autism spectrum disorder diagnosis using machine learning techniques.

DNA methylation mediates the link between adversity and depressive symptoms (2024)
Journal Article

Experiences of childhood adversity can double risk for depression. Although the mechanisms underlying this relationship remain unclear, DNA methylation (DNAm) has emerged as a potential pathway to explain the link between adversity and depression. Th... Read More about DNA methylation mediates the link between adversity and depressive symptoms.

Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may be a better option than mastectomy, but high-quality comparative evidence is lacking. The ANTHEM study (ISRCTN18238549) aimed to explore clinical and patient-reported outcomes... Read More about Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study.

Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study (2024)
Journal Article

Introduction
Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery of feed throughout the day and night. Emerging evidence from healthy human s... Read More about Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study.

Developmental timing of associations among parenting, brain architecture, and mental health (2024)
Journal Article

Importance
Parenting is associated with brain development and long-term health outcomes, although whether these associations depend on the developmental timing of exposure remains understudied. Identifying these sensitive periods can inform when and... Read More about Developmental timing of associations among parenting, brain architecture, and mental health.

Life-course influences of poverty on violence and homicide: 30-year Brazilian birth cohort study (2024)
Journal Article

Background: Homicide is the leading cause of death among young people in Latin America, one of the world's most violent regions. Poverty is widely considered a key cause of violence, but theories suggest different effects of poverty, depending on whe... Read More about Life-course influences of poverty on violence and homicide: 30-year Brazilian birth cohort study.

Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may allow women with early breast cancer to avoid mastectomy, but many women choose more extensive surgery even when breast conserving options are offered. Reasons for this are un... Read More about Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study.

Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis (2024)
Journal Article

Background. Depression is a common mental health disorder that often starts during adolescence, with potentially important future consequences including ‘Not in Education, Employment or Training’ (NEET) status. Methods. We took a structured life cour... Read More about Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis.

Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine? (2024)
Journal Article

Background: Clinical acumen represents only part of being adequately equipped to attend a major incident. The emotive sights, sounds and smells of these dynamic environments are all-encompassing experiences, and responders must also be armed with the... Read More about Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine?.

Changes in attitudes towards telemedicine in acute burn care following the Covid-19 pandemic   (2024)
Journal Article

Background: Telemedical referrals after burn injury had been shown to be advantageous over telephone referrals for multiple reasons, however there were several key barriers towards complete implementation. The Covid-19 pandemic facilitated the adopti... Read More about Changes in attitudes towards telemedicine in acute burn care following the Covid-19 pandemic  .

How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey (2024)
Journal Article

Objectives: Naturally exfoliated primary teeth are being increasingly collected in child development studies. Most of these odontological collections and tooth biobanks use parent-reported information from questionnaires or tooth checklists to collec... Read More about How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey.

The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts (2024)
Journal Article

Background: Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure t... Read More about The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts.

Project-based learning integrated with e-Assessment (2024)
Journal Article

This paper explores a recent move towards project-based learning for a first-year undergraduate statistics module at the University of the West of England, Bristol. The course is aimed at students specialising in Mathematics and Statistics. A classro... Read More about Project-based learning integrated with e-Assessment.

Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons (2024)
Journal Article

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway... Read More about Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.

The inadvertently revealing statistic: A systemic gap in statistical training? (2024)
Journal Article

While concerns around data privacy are well-known, there's a lack of awareness and training when it comes to the confidentiality risk of published statistics, argue Ben Derrick, Elizabeth Green, Felix Ritchie, Jim Smith, Paul White

The incidence of physician-diagnosed food allergy declines with age: A specialist UK centre experience (2023)
Journal Article

The incidence of physician-diagnosed food allergy declined with age in a cohort of UK adults.

Men were more likely to be diagnosed with food allergy than women.

The incidence of shellfish, wheat & cereals and vegetable & herb allergies increase... Read More about The incidence of physician-diagnosed food allergy declines with age: A specialist UK centre experience.

Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study (2023)
Journal Article

BACKGROUND: Breast reconstruction is offered to improve quality of life for women after mastectomy for breast cancer, but information regarding the long-term patient-reported outcomes of different reconstruction procedures is currently lacking. The B... Read More about Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study.

The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom) (2023)
Journal Article

Background: Decreasing rates of assisted vaginal birth have been paralleled with increasing rates of cesarean deliveries over the last 40 years. The OdonAssist is a novel device for assisted vaginal birth. Iterative changes to clinical parameters, de... Read More about The OdonAssist inflatable device for assisted vaginal birth—the ASSIST II study (United Kingdom).

A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization (2023)
Journal Article

Background: Blood pressure measurement is a standard of monitoring during general anesthesia. Invasive measurement is considered the gold standard but is less commonly used than non-invasive. Automated oscillometric blood pressure devices measure the... Read More about A prospective comparison of invasive and non‐invasive blood pressure in children undergoing cardiac catheterization.

Oncological outcomes after transanal total mesorectal excision for rectal cancer (2023)
Journal Article

Transanal total mesorectal excision (TaTME) was developed to overcome the technical difficulties of a transabdominal minimal-access approach to resection of low rectal cancer1–4. TaTME was reported to be feasible and effective, with the potential adv... Read More about Oncological outcomes after transanal total mesorectal excision for rectal cancer.