Skip to main content

Research Repository

Advanced Search

All Outputs (107)

Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression (2012)
Journal Article

Steroid metabolism is important in various species. The accumulation of androgen metabolite, androstenone, in pig adipose tissue is negatively associated with pork flavor, odour and makes the meat unfit for human consumption. The 17β-hydroxysteroid d... Read More about Investigation of Testosterone, Androstenone, and Estradiol Metabolism in HepG2 Cells and Primary Culture Pig Hepatocytes and Their Effects on 17βHSD7 Gene Expression.

The effect of pressure and mobile phase velocity on the retention properties of small analytes and large biomolecules in ultra-high pressure liquid chromatography (2012)
Journal Article

A possible complication of ultra-high pressure liquid chromatography (UHPLC) is related to the effect of pressure and mobile phase velocity on the retention properties of the analytes. In the present work, numerous model compounds have been selected... Read More about The effect of pressure and mobile phase velocity on the retention properties of small analytes and large biomolecules in ultra-high pressure liquid chromatography.

EACR poster prize winner for "Autolysosomal β-catenin degradation regulates Wnt-autophagy/p62 crosstalk" (2012)
Presentation / Conference Contribution

(EACR Poster Prize) The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both ba... Read More about EACR poster prize winner for "Autolysosomal β-catenin degradation regulates Wnt-autophagy/p62 crosstalk".

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation (2012)
Journal Article

The branched chain aminotransferase enzymes (BCAT) serve as nitrogen donors for the production of 30% of de novo glutamate synthesis in rat brain. Despite the importance of this major metabolite and excitatory neurotransmitter, the distribution of BC... Read More about Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles (2012)
Journal Article

This study investigated effects of roasted or extruded oilseed supplementation ranging in n-6/n-3 ratios from 0.3 to 5.0 on the fatty acid composition and expression of delta-5 desaturase (δ5d) and δ6-desaturase (δ6d) protein in commercial steer chee... Read More about Influence of oilseed supplement ranging in n-6/n-3 ratio on fatty acid composition and δ5-, δ6-desaturase protein expression in steer muscles.

Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination (2012)
Journal Article

A recent shift by the scientific and regulatory community, towards accepting the existence of non-linear dose responses for certain DNA reactive genotoxic agents, has unveiled a myriad of questions regarding their biological basis. The mechanisms res... Read More about Investigating mechanisms for non-linear genotoxic responses, and analysing their effects in binary combination.

Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science (2012)
Thesis

Open science, a practice in which the entirety of a research project is made available, via the Internet, using a variety of tools and techniques, is an emerging approach to the conduct of science. The hypothesis that open science therefore has the p... Read More about Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science.

The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine (2012)
Journal Article

Screen-printed carbon electrodes (SPCEs) incorporating the electrocatalyst cobalt phthalocyanine (CoPC) have been successfully used for the manufacture of microband electrodes for the determination of reduced glutathione (GSH). Initially investigati... Read More about The chronoamperometric and voltammetric behaviour of glutathione at screen-printed carbon micro-band electrodes modified with cobalt phthalocyanine.

Sleep specialists' opinion on sleep disorders and fitness to drive a car: The necessity of continued education (2012)
Journal Article

Whether patients with sleep disorders are fit to drive, and who should determine this, is a matter of debate. However, scientific literature is available on these topics to aid clinicians making these decisions. A survey was conducted to assess sleep... Read More about Sleep specialists' opinion on sleep disorders and fitness to drive a car: The necessity of continued education.

Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing (2012)
Journal Article

Impedance-based cytotoxicity testing provides a simple, real-time and non-invasive assay technique that interferes minimally with cell morphology and function. In this study, impedimetric measurements of ECV304 cells with increasing concentrations of... Read More about Robust feature extraction from impedimetric signals using wavelet packet decomposition with application to cytotoxicity testing.

BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells (2012)
Journal Article

As colorectal cancer remains the second highest cause of cancer-related deaths in much of the industrialised world, identifying novel strategies to prevent colorectal tumour development remains an important challenge. BAG-1 is a multi-functional prot... Read More about BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells.

Analyzing sward and plant species make-up of sports and amenity turf, involves analyzing presence of genetic markers e.g. ribulose-bisphosphate carboxylase gene in sward sample obtained from sports or amenity turf surfaces (2012)
Patent

Abstract: NOVELTY - Method for analyzing sward, involves analyzing a sample of sward for the presence of one or more genetic markers, where the one or more genetic markers indicates the presence, identity and/or relative abundance of one or more spec... Read More about Analyzing sward and plant species make-up of sports and amenity turf, involves analyzing presence of genetic markers e.g. ribulose-bisphosphate carboxylase gene in sward sample obtained from sports or amenity turf surfaces.

Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies (2012)
Journal Article

HHARI (also known as ARIH1) is an ubiquitin-protein ligase and is the cognate of the E2, UbcH7 (UBE2L3). To establish a functional role for HHARI in cellular proliferation processes, we performed a reverse genetics screen that identified n=86/522 (16... Read More about Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.