All Outputs (83)

Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy (2013)
Journal Article

Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy. 92 An evaluative assay to determine resistance/sensitivity to ara- C prior... Read More about Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy.

Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment (2013)
Journal Article

The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and... Read More about Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment.

Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors (2013)
Journal Article

A device for measuring human breath ammonia was developed based on a single use, disposable, inkjet printed ammonia sensor fabricated using polyaniline nanoparticles. The device was optimized for sampling ammonia in human breath samples by addressing... Read More about Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors.

A case study in serendipity: Environmental researchers use of traditional and social media for dissemination (2013)
Journal Article

In the face of demands for researchers to engage more actively with a wider range of publics and to capture different kinds of research impacts and engagements, we explored the ways a small number of environmental researchers use traditional and soci... Read More about A case study in serendipity: Environmental researchers use of traditional and social media for dissemination.

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis (2013)
Journal Article

The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires thespatiotemporal coordination of multi... Read More about RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.

Values associated with public involvement in health and social care research: A narrative review (2013)
Journal Article

© 2015 John Wiley & Sons Ltd. Background: Much has been written about public involvement (PI) in health and social care research, but underpinning values are rarely made explicit despite the potential for these to have significant influence on the... Read More about Values associated with public involvement in health and social care research: A narrative review.

Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples (2013)
Journal Article

In this study we investigated the possibility of applying Ag electrodes manufactured from recordable rewritable digital versatile discs (DVD-RW) for the voltammetric determination of hydrogen peroxide. The calibration plot was linear from 0.087 mM to... Read More about Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples.

Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice (2013)
Journal Article

Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for S N 1 and S N 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining no... Read More about Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria (2013)
Journal Article

Summary: The rulAB operon of Pseudomonas spp. confers fitness traits on the host and has been suggested to be a hotspot for insertion of mobile elements that carry avirulence genes. Here, for the first time, we show that rulB on plasmid pWW0 is a hot... Read More about The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria.

A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production (2013)
Journal Article

Pseudomonas syringae pv. syringae, the causal agent of bacterial apical necrosis (BAN) in mango crops, has been isolated in different mango-producing areas worldwide. An extensive collection of 87 P. syringae pv. syringae strains isolated from mango... Read More about A Pseudomonas syringae diversity survey reveals a differentiated phylotype of the pathovar syringae associated with the mango host and mangotoxin production.

What are the costs and benefits of patient notification exercises following poor infection control practices in dentistry? (2013)
Journal Article

Background: Allegations of serious failures in infection control practice were made against a dentist practicing in the South West of England. The dentist (who tested negative for Blood Borne Viruses (BBVs)) was immediately suspended. Methods: Becaus... Read More about What are the costs and benefits of patient notification exercises following poor infection control practices in dentistry?.

In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A (2013)
Journal Article

Pseudomonas syringae pv. phaseolicola (Pph) strain 1302A, a causative agent of halo blight in the common bean Phaseolus vulgaris, contains four native plasmids designated pAV505 (150. kb), pAV506 (50. kb), pAV507 (47. kb) and pAV508 (42. kb). Pph 130... Read More about In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A.

Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood (2013)
Journal Article

Epidemiological studies show that elevated plasma levels of advanced glycation end products (AGEs) are associated with diabetes, kidney disease, and heart disease. Thus AGEs have been used as disease progression markers. However, the effects of varia... Read More about Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood.

Isolation of human genomic DNA for genetic analysis from premature neonates: A comparison between newborn dried blood spots, whole blood and umbilical cord tissue (2013)
Journal Article

Background: Genotyping requires biological sample collection that must be reliable, convenient and acceptable for patients and clinicians. Finding the most optimal procedure of sample collection for premature neonates who have a very limited blood vo... Read More about Isolation of human genomic DNA for genetic analysis from premature neonates: A comparison between newborn dried blood spots, whole blood and umbilical cord tissue.

Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance (2013)
Journal Article

The coagulation of blood plasma and the effect of fibrinogen concentration were studied with a quartz crystal microbalance (QCM), where frequency and half-width at half-maximum (bandwidth) values measured from the conductance spectrum near resonant f... Read More about Measurement of the evolution of rigid and viscoelastic mass contributions from fibrin network formation during plasma coagulation using quartz crystal microbalance.

Comparative assessment of the ELBA coarse-grained model for water (2013)
Journal Article

The ELBA force field for water consists of a single spherical site embedded with a point dipole. This coarse-grained model is assessed here through the calculation of fundamental properties of bulk liquid water and the water-vapour interface. Accurac... Read More about Comparative assessment of the ELBA coarse-grained model for water.

A new approach to predicting environmental transfer of radionuclides to wildlife: A demonstration for freshwater fish and caesium (2013)
Journal Article

The application of the concentration ratio (CR) to predict radionuclide activity concentrations in wildlife from those in soil or water has become the widely accepted approach for environmental assessments. Recently both the ICRP and IAEA have produc... Read More about A new approach to predicting environmental transfer of radionuclides to wildlife: A demonstration for freshwater fish and caesium.

Stabilising solar ponds by utilising porous materials (2013)
Journal Article

The linear instability of a solar pond containing porous material in the lower convective zone (LCZ) is investigated. It is found that, in general, for physically realistic values, solar ponds that contain porous material are more stable than ones th... Read More about Stabilising solar ponds by utilising porous materials.

Coagulation-monitoring devices at the point of care (2013)
Journal Article

With the advent of point-of-care (POC) testing, the working principle of traditional coagulometers was used as the foundation for the development of miniaturized devices. This review highlights recent progress in the development of POC coagulation-m... Read More about Coagulation-monitoring devices at the point of care.

Involving patients and the public in healthcare operational research-The challenges and opportunities (2013)
Journal Article

Interest is growing internationally in the potential benefits of patient and public involvement (PPI) in research. In the United Kingdom (UK) health and social care services are now committed to involving patients and service users in the planning, d... Read More about Involving patients and the public in healthcare operational research-The challenges and opportunities.