All Outputs (61)

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Uzor, S., Porazinski, S., Li, L., Clark, B., Ajiro, M., Iida, K., …Ladomery, M. (2021). CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Scientific Reports, 11(1), Article 7963. https://doi.org/10.1038/s41598-021-86908-6

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

‘We tend to get pad happy’: A qualitative study of health practitioners’ perspectives on the quality of continence care for older people in hospital (2021)
Journal Article
Percival, J., Abbott, K., Allain, T., Bradley, R., Cramp, F., Donovan, J. L., …Cotterill, N. (2021). ‘We tend to get pad happy’: A qualitative study of health practitioners’ perspectives on the quality of continence care for older people in hospital. BMJ Open Quality, 10(2), Article e001380. https://doi.org/10.1136/bmjoq-2021-001380

Bladder and bowel control difficulties affect 20% and 10% of the UK population, respectively, touch all age groups and are particularly prevalent in the older (65+ years) population. However, the quality of continence care is often poor, compromising... Read More about ‘We tend to get pad happy’: A qualitative study of health practitioners’ perspectives on the quality of continence care for older people in hospital.

5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis (2021)
Journal Article
Dixon, S. W., Collard, T. J., Mortensson, E. M. H., Legge, D. N., Chambers, A. C., Greenhough, A., …Williams, A. C. (2021). 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis. British Journal of Cancer, 124, 1959–1969. https://doi.org/10.1038/s41416-021-01354-5

Background: Most colorectal cancers (CRC) arise sporadically from precursor lesions: colonic polyps. Polyp resection prevents progression to CRC. Risk of future polyps is proportional to the number and size of polyps detected at screening, allowing i... Read More about 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis.

Developing a systematic method for extraction of microplastics in soils (2021)
Journal Article
Radford, F., Zapata-Restrepo, L. M., Horton, A. A., Hudson, M. D., Shaw, P. J., & Williams, I. D. (2021). Developing a systematic method for extraction of microplastics in soils. Analytical Methods, 13(14), 1695-1705. https://doi.org/10.1039/d0ay02086a

Microplastics are an environmental issue of global concern. Although they have been found in a range of environments worldwide, their contamination in the terrestrial environment is poorly understood. The lack of standardised methods for their detect... Read More about Developing a systematic method for extraction of microplastics in soils.

A roadmap for genome-based phage taxonomy (2021)
Journal Article
Turner, D., Kropinski, A. M., & Adriaenssens, E. M. (2021). A roadmap for genome-based phage taxonomy. Viruses, 13(3), Article 506. https://doi.org/10.3390/v13030506

Bacteriophage (phage) taxonomy has been in flux since its inception over four decades ago. Genome sequencing has put pressure on the classification system and recent years have seen significant changes to phage taxonomy. Here, we reflect on the state... Read More about A roadmap for genome-based phage taxonomy.

Brachytherapy for locally advanced cervical cancer: A survey of UK provision of care and support (2021)
Journal Article
Humphrey, P., Dures, E., Hoskin, P., & Cramp, F. (2021). Brachytherapy for locally advanced cervical cancer: A survey of UK provision of care and support. Radiotherapy and Oncology, 159, 60-66. https://doi.org/10.1016/j.radonc.2021.03.007

Background and purpose: Gynaecological brachytherapy can cause anxiety, distress and discomfort. It is not known how variation in delivery impacts women's experiences. To inform future research an online survey was carried out to identify variations... Read More about Brachytherapy for locally advanced cervical cancer: A survey of UK provision of care and support.

Formation of furan in baby food products: Identification and technical challenges (2021)
Journal Article
Javed, F., Shahbaz, H. M., Nawaz, A., Olaimat, A. N., Stratakos, A. C., Wahyono, A., …Park, J. (2021). Formation of furan in baby food products: Identification and technical challenges. Comprehensive Reviews in Food Science and Food Safety, 20(3), 2699-2715. https://doi.org/10.1111/1541-4337.12732

Furan is generally produced during thermal processing of various foods including baked, fried, and roasted food items such as cereal products, coffee, canned, and jarred prepared foods as well as in baby foods. Furan is a toxic and carcinogenic compo... Read More about Formation of furan in baby food products: Identification and technical challenges.

Shaping more resilient and just food systems: Lessons from the COVID-19 Pandemic (2021)
Journal Article
Sanderson Bellamy, A., Furness, E., Nicol, P., Pitt, H., & Taherzadeh, A. (2021). Shaping more resilient and just food systems: Lessons from the COVID-19 Pandemic. AMBIO: A Journal of the Human Environment, 50, 782-793. https://doi.org/10.1007/s13280-021-01532-y

The COVID-19 pandemic has highlighted weaknesses in global food systems, as well as opening windows of opportunity for innovation and transformation. While the nature and extent of this crisis is rare, extreme climatic events will increase in magnitu... Read More about Shaping more resilient and just food systems: Lessons from the COVID-19 Pandemic.

Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period (2021)
Journal Article
Silveira, N. M., Ribeiro, R. V., de Morais, S. F. N., de Souza, S. C. R., da Silva, S. F., Seabra, A. B., …Machado, E. C. (2021). Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period. Plant Physiology and Biochemistry, 162, 315-326. https://doi.org/10.1016/j.plaphy.2021.02.036

© 2021 Elsevier Masson SAS Arginine (Arg) metabolism is associated with many cellular and developmental processes in plants and proline, nitric oxide (NO) and polyamines (PAs) have a wide range of physiological functions in plants, including increase... Read More about Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period.

3D scaffolds in the treatment of diabetic foot ulcers: New trends vs conventional approaches (2021)
Journal Article
Glover, K., Ch. Stratakos, A., Varadi, A., & Lamprou, D. A. (2021). 3D scaffolds in the treatment of diabetic foot ulcers: New trends vs conventional approaches. International Journal of Pharmaceutics, 599, https://doi.org/10.1016/j.ijpharm.2021.120423

Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus, affecting roughly 25% of diabetic patients and resulting in lower limb amputation in over 70% of known cases. In addition to the devastating physiological consequences of DFU a... Read More about 3D scaffolds in the treatment of diabetic foot ulcers: New trends vs conventional approaches.

The UK forensic science regulator: Fit for purpose? (2021)
Journal Article
Nsiah Amoako, E., & McCartney, C. (2021). The UK forensic science regulator: Fit for purpose?. Wiley Interdisciplinary Reviews: Forensic Science, 3(6), e1415. https://doi.org/10.1002/wfs2.1415

The role of Forensic Science Regulator (FSR), created in 2007, was established to assure the achievement and maintenance of forensic science service (FSS) provision that commands public confidence. The FSR works at an organizational level, to assure,... Read More about The UK forensic science regulator: Fit for purpose?.

Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – Mass spectrometry (2021)
Journal Article
Lardeux, H., Duivelshof, B. L., Colas, O., Beck, A., McCalley, D. V., Guillarme, D., & D’Atri, V. (2021). Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – Mass spectrometry. Analytica Chimica Acta, 1156, Article 338347. https://doi.org/10.1016/j.aca.2021.338347

When analyzing large complex protein biopharmaceuticals, ion-pairing agents imparting low pH are widely used as mobile phase additives to improve the chromatographic performance. However, one of the most effective additives in RPLC and HILIC, trifluo... Read More about Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – Mass spectrometry.

Current provision of general practitioner services in or alongside emergency departments in England (2021)
Journal Article
Brant, H., Voss, S., Morton, K., Cooper, A., Edwards, M., Price, D., …Benger, J. (2021). Current provision of general practitioner services in or alongside emergency departments in England. Emergency Medicine Journal, 38(10), 780-783. https://doi.org/10.1136/emermed-2020-210539

Background: In 2017, general practitioners in or alongside the emergency department (GPED), an approach that employs GPs in or alongside the ED to address increasing ED demand, was advocated by the National Health Service in England and supported by... Read More about Current provision of general practitioner services in or alongside emergency departments in England.

Peaks in bat activity at turbines and the implications for mitigating the impact of wind energy developments on bats (2021)
Journal Article
Richardson, S., Lintott, P., Hosken, D., Economou, T., & Mathews, F. (2021). Peaks in bat activity at turbines and the implications for mitigating the impact of wind energy developments on bats. Scientific Reports, 11(1), Article 3636. https://doi.org/10.1038/s41598-021-82014-9

Wind turbines are a relatively new threat to bats, causing mortalities worldwide. Reducing these fatalities is essential to ensure that the global increase in wind-energy facilities can occur with minimal impact on bat populations. Although individua... Read More about Peaks in bat activity at turbines and the implications for mitigating the impact of wind energy developments on bats.

Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities (2021)
Journal Article
Szemes, M., Melegh, Z., Bellamy, J., Park, J. H., Chen, B., Greenhough, A., …Malik, K. (2021). Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities. Cancers, 13(4), Article 656. https://doi.org/10.3390/cancers13040656

The MYCN proto-oncogene is deregulated in many cancers, most notably in neuroblastoma, where MYCN gene amplification identifies a clinical subset with very poor prognosis. Gene expression and DNA analyses have also demonstrated overexpression of MYCN... Read More about Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities.

Peoples’ experiences of painful diabetic neuropathy: Are pain management programmes appropriate? (2021)
Journal Article
Davies, B., Cramp, F., Gauntlett-Gilbert, J., & McCabe, C. S. (2021). Peoples’ experiences of painful diabetic neuropathy: Are pain management programmes appropriate?. British Journal of Pain, 15(4), 450-459. https://doi.org/10.1177/2049463721989753

Objective: Painful diabetic neuropathy (PDN) is a painful complication of diabetes. This study aimed to explore: (1) strategies used by participants to manage impacts of PDN and (2) their perspectives on whether strategies from pain management progra... Read More about Peoples’ experiences of painful diabetic neuropathy: Are pain management programmes appropriate?.

Using UAV-mounted thermal cameras to detect the presence of nesting nightjar in upland clear-fell: A case study in South Wales, UK (2021)
Journal Article
Shewring, M. P., & Vafidis, J. O. (2021). Using UAV-mounted thermal cameras to detect the presence of nesting nightjar in upland clear-fell: A case study in South Wales, UK. Ecological Solutions and Evidence, 2(1), Article e12052. https://doi.org/10.1002/2688-8319.12052

1. Confirming the presence and location of European Nightjar Caprimulgus europaeus nests is a significant fieldwork challenge in ecological monitoring. Nest sites can be located through direct observation or capture and radio tracking of breeding ind... Read More about Using UAV-mounted thermal cameras to detect the presence of nesting nightjar in upland clear-fell: A case study in South Wales, UK.

Management of fatigue with physical activity and behavioural change support in vasculitis: A feasibility study (2021)
Journal Article
Harper, L., Hewitt, C. A., Litchfield, I., Morgan, M. D., Chanouzas, D., Caulfield, H. K., …Daley, A. J. (2021). Management of fatigue with physical activity and behavioural change support in vasculitis: A feasibility study. Rheumatology, 60(9), 4130-4140. https://doi.org/10.1093/rheumatology/keaa890

OBJECTIVE: Patients with ANCA-associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomized controlled trial of a behavioural-based physical... Read More about Management of fatigue with physical activity and behavioural change support in vasculitis: A feasibility study.

Use of a nitrification inhibitor reduces nitrous oxide (N2O) emissions from compacted grassland with different soil textures and climatic conditions (2021)
Journal Article
Hargreaves, P. R., Baker, K. L., Graceson, A., Bonnett, S. A., Ball, B. C., & Cloy, J. M. (2021). Use of a nitrification inhibitor reduces nitrous oxide (N2O) emissions from compacted grassland with different soil textures and climatic conditions. Agriculture, Ecosystems and Environment, 310, Article 107307. https://doi.org/10.1016/j.agee.2021.107307

Grassland accounts for 70 % of the global agricultural area. Grassland amended with N fertiliser, although increasing productivity, encourages the emission of the greenhouse gas nitrous oxide (N2O). Soil compaction can result in impeded water movemen... Read More about Use of a nitrification inhibitor reduces nitrous oxide (N2O) emissions from compacted grassland with different soil textures and climatic conditions.

Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi (2021)
Journal Article
Kumwenda, P., Adukwu, E. C., Tabe, E. S., Ujor, V. C., Kamudumuli, P. S., Ngwira, M., …Chisale, M. (2021). Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi. BMC Infectious Diseases, 21, Article 34. https://doi.org/10.1186/s12879-020-05725-w

Background: Bacterial infections are a significant cause of sickness and death in sub-Saharan Africa. This study aimed at establishing the prevalence, distribution and antimicrobial susceptibility pattern of major bacterial isolates from patients acc... Read More about Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi.