3D scaffolds in the treatment of diabetic foot ulcers: New trends vs conventional approaches

Glover, Katie; Ch. Stratakos, Alexandros; Varadi, Aniko; Lamprou, Dimitrios A.

Abstract

Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus, affecting roughly 25% of diabetic patients and resulting in lower limb amputation in over 70% of known cases. In addition to the devastating physiological consequences of DFU and its impact on patient quality of life, DFU has significant clinical and economic implications. Various traditional therapies are implemented to effectively treat DFU. However, emerging technologies such as bioprinting and electrospinning, present an exciting opportunity to improve current treatment strategies through the development of 3D scaffolds, by overcoming the limitations of current wound healing strategies. This review provides a summary on (i) current prevention and treatment strategies available for DFU; (ii) methods of fabrication of 3D scaffolds relevant for this condition; (iii) suitable materials and commonly used molecules for the treatment of DFU; and (iv) future directions offered by emerging technologies.

• Journal Article Type: Article
• Acceptance Date: Feb 20, 2021
• Online Publication Date: Feb 27, 2021
• Publication Date: Apr 15, 2021
• Deposit Date: Jun 25, 2021
• Journal: International Journal of Pharmaceutics
• Print ISSN: 0378-5173
• Electronic ISSN: 1873-3476
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 599
• Article Number: 120423
• DOI: https://doi.org/10.1016/j.ijpharm.2021.120423
• Keywords: Pharmaceutical Science
• Public URL: https://uwe-repository.worktribe.com/output/7161108