All Outputs (289)

Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons (2023)
Journal Article

The principles of evidence-based medicine (EBM) are the foundation of modern medical practice. Surgeons are familiar with the commonly used statistical techniques to test hypoth-eses, summarize findings, and provide answers within a specified range o... Read More about Acceptance and understanding of artificial intelligence in medical research among orthopaedic surgeons.

Diversity and inclusion: Creating a culture of equity in the biosciences (2023)
Presentation / Conference Contribution

Abstract: Globally, science remains exclusive and inequalities continue for minoritised communities in the UK, US and across the world. Access to learning resources, quality of learning experiences and graduate outcomes continues to impact minoritise... Read More about Diversity and inclusion: Creating a culture of equity in the biosciences.

Characterisation of the UK high energy proton research beamline for high and ultra-high dose rate (FLASH) irradiation (2023)
Journal Article

Objective. This work sets out the capabilities of the high energy proton research beamline developed in the Christie proton therapy centre for Ultra-High Dose Rate (UHDR) irradiation and FLASH experiments. It also characterises the lower limits of UH... Read More about Characterisation of the UK high energy proton research beamline for high and ultra-high dose rate (FLASH) irradiation.

NOTCH and AKT signalling interact to drive mammary tumour heterogeneity (2023)
Journal Article

A better understanding of the mechanisms generating tumour heterogeneity will allow better targeting of current therapies, identify potential resistance mechanisms and highlight new approaches for therapy. We have previously shown that in genetically... Read More about NOTCH and AKT signalling interact to drive mammary tumour heterogeneity.

Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..

PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate (2023)
Journal Article

The PIP3/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP3/PI(3,4)P2 phosphatase, PTEN. Despite huge research investment, the drivers of the PI3K network in normal tissues and how th... Read More about PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.

Our universe is humming with gravitational waves (2023)
Digital Artefact

In recent weeks the astrophysics community has been buzzing following the discovery that the universe appears to be filled with a background hum of gravitational waves. Using radio telescopes in the Africa, Asia, Australia, Europe and the US, several... Read More about Our universe is humming with gravitational waves.

The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method (2023)
Journal Article

In this study, liposomes enclosing eugenol were prepared using microfluidics. Two lipids—1,2-dimyristoyl-sn-glycero-3-phosphocholine, 18:0 (DSPC) and 2-dimyristoyl-sn-glycero-3-phosphocholine, 14:0 (DMPC)—and microfluidic chips with serpentine and Y-... Read More about The manufacturing and characterisation of eugenol-enclosed liposomes produced by microfluidic method.

Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry (2023)
Journal Article

A liquid chromatography-tandem mass spectrometry screening method in sweat was developed for the simultaneous determination of three licit drugs (nicotine, paracetamol, and caffeine); four illicit drugs (cocaine, ketamine, 25I-NBOMe and methamphetami... Read More about Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry.

Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds (2023)
Journal Article

With the rapidly expanding global nuclear industry, more efficient and direct radiological monitoring approaches are needed to ensure the associated environmental health impacts and risk remain fully assessed and undertaken as robustly as possible. C... Read More about Enhancing radiological monitoring of 137Cs in coastal environments using taxonomic signals in brown seaweeds.

The effects of herbal teas and supplements on the human microbiota and metabolism (2023)
Presentation / Conference Contribution

Background: For centuries, herbal teas have been consumed by people of all ages and has been used for therapy in different civilisations and medical systems such as the Chinese, Indian, indigenous, and African. The aphorism- ‘Nature is the best chemi... Read More about The effects of herbal teas and supplements on the human microbiota and metabolism.

Editorial: The use of volatile compounds analysis for the assessment of food and beverage quality (2023)
Journal Article

Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources (2023)
Journal Article

It is estimated that the world will need an extra 265 million tons of protein by the middle of this century, which is approximately 50 % more than today. Efforts are currently underway to find sustainable protein sources for keepin... Read More about Recent advances in microalgae, insects, and cultured meat as sustainable alternative protein sources.

Detecting sleep‐related breathing disorders using overnight pulse oximetry in patients with dementia and mild cognitive impairment (2023)
Presentation / Conference Contribution

AbstractBackgroundSleep disturbance is commonly reported in Alzheimer’s disease (AD), Lewy body dementia (LBD) and mild cognitive impairment (MCI). Early identification of sleep changes is crucial as poor sleep could contribute to cognitive decline a... Read More about Detecting sleep‐related breathing disorders using overnight pulse oximetry in patients with dementia and mild cognitive impairment.

An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation (2023)
Journal Article

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo... Read More about An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation.

Ventilatory efficiency is reduced in people with hypertension during exercise (2023)
Journal Article

BACKGROUND: An elevated ventilatory efficiency slope during exercise (minute ventilation/volume of expired CO2; VE /VCO2 slope) is a strong prognostic indicator in heart failure. It is elevated in people with heart failure with preserved ejection, ma... Read More about Ventilatory efficiency is reduced in people with hypertension during exercise.

Teaching data analysis to life scientists using “R” statistical software: Challenges, opportunities, and effective methods (2023)
Book Chapter

Data analysis is one of the most important and empowering transferable skills that a scientist can possess; yet many life scientists find statistics a daunting subject that they perceive as difficult to master. In this paper, we reflect on our experi... Read More about Teaching data analysis to life scientists using “R” statistical software: Challenges, opportunities, and effective methods.

Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow (2023)
Journal Article

Donor cell leukaemia (DCL) is a complication of haematopoietic stem cell transplantation where donated cells become malignant within the patient's bone marrow. As DCL predominates as acute myeloid leukaemia, we hypothesized that the cytokine storm fo... Read More about Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow.

The effects of herbal teas and supplements on the human microbiota and metabolism (2023)
Presentation / Conference Contribution

Background: For centuries, herbal teas have been consumed by people of all ages and has been used for therapy in different civilisations and medical systems such as the Chinese, Indian, indigenous, and African. The aphorism- ‘Nature is the best chemi... Read More about The effects of herbal teas and supplements on the human microbiota and metabolism.

Cosmic generosity: A selfless investment in the future of physics (2023)
Digital Artefact

If you were awarded $3m prize money for your scientific excellence and hard graft, would you give it all away to strangers? That’s what the Northern Irish astrophysicist Dame Jocelyn Bell Burnell did in 2018 after winning the Special Breakthrough Pri... Read More about Cosmic generosity: A selfless investment in the future of physics.