All Outputs (289)

Recent knowledge on the applications of molecular hydrogen in plant physiology, crop production, and food processing (2024)
Journal Article

This is an Editorial for a Topics Issue. It briefly summarises the field, highlighting its importance. It also gives a brief overview of each of the papers published in that issue.

An example of the views of educators on incorporating the sustainable development goals into engineering and environmental school engagement activities using Minecraft (2024)
Journal Article

The United Nations adopted the Sustainable Development Goals in 2015 as a call to “end poverty, protect the planet, and ensure that by 2030 all people enjoy peace and prosperity”. The UK-based Science Hunters programme uses Minecraft to engage childr... Read More about An example of the views of educators on incorporating the sustainable development goals into engineering and environmental school engagement activities using Minecraft.

Interleukins in urine and blood as markers of infection and as risk factors for systemic conditions (2024)
Journal Article

Interleukins are a diverse group of cytokines that play a crucial role in controlling immune responses and have potential as biomarkers. This mini review evaluates 12 recent papers linking urinary interleukins to both urinary infection and systemic d... Read More about Interleukins in urine and blood as markers of infection and as risk factors for systemic conditions.

Emulating the delivery of sawtooth proton arc therapy plans on a cyclotron-based proton beam therapy system (2024)
Journal Article

Purpose: To evaluate and compare the deliverability of ‘sawtooth’ proton arc therapy (PAT) plans relative to static intensity modulated proton therapy (IMPT) at a cyclotron-based clinical facility.

Methods: The delivery of single and dual arc Saw... Read More about Emulating the delivery of sawtooth proton arc therapy plans on a cyclotron-based proton beam therapy system.

Identifying targetable metabolic dependencies across colorectal cancer progression (2024)
Journal Article

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet... Read More about Identifying targetable metabolic dependencies across colorectal cancer progression.

Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways (2024)
Journal Article

Approximately 50% of poor prognosis neuroblastomas arise due to MYCN over-expression. We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 knockdown led to apoptosis of MYCN amplified (MNA) neuroblastoma. Here we evaluate the hi... Read More about Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

An anodic stripping voltammetric approach for total mercury determination in sea sponges from the Niger Delta region of Nigeria (2024)
Journal Article

Mercury pollution from ongoing crude oil refining and waste disposal activities threatens aquatic ecosystems and human health in the Niger Delta. Mercury monitoring exercise in this region is challenging due to the high cost of traditional instrument... Read More about An anodic stripping voltammetric approach for total mercury determination in sea sponges from the Niger Delta region of Nigeria.

Molecular hydrogen: A sustainable strategy for agricultural and food production challenges (2024)
Journal Article

The world is confronting numerous challenges, including global warming, health epidemics, and population growth, each presenting significant threats to the stability and sustainability of our planet's ecosystems. Such issues have collectively contrib... Read More about Molecular hydrogen: A sustainable strategy for agricultural and food production challenges.

Recording and reporting of ultra-high dose rate “FLASH” delivery for preclinical and clinical settings (2024)
Journal Article

Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic index of radiation therapy (RT) by sparing normal tissues compared to conventional dose rate irradiations. Insufficient and inconsistent reporting in physics and... Read More about Recording and reporting of ultra-high dose rate “FLASH” delivery for preclinical and clinical settings.

Advances in cancer diagnosis and treatment (2024)
Journal Article

This Special Issue of the British Journal of Biomedical Science brings together a collection of articles which all contribute to the advancement of knowledge into the diagnosis and treatment of cancer. Each article in this diverse research field offe... Read More about Advances in cancer diagnosis and treatment.

Sensing solutions in soil biodiversity and carbon monitoring; from acoustics to biosensing (2024)
Presentation / Conference Contribution

This presentation formed an overview of the current research into the technologies we are developing in SOAS at UWE for the analysis of soil carbon dynamics and soil biodiversity. It highlights three main strands; electrochemical (bio)sensing, gas s... Read More about Sensing solutions in soil biodiversity and carbon monitoring; from acoustics to biosensing.

Interorgan, intraorgan and interplant communication mediated by nitric oxide and related species (2024)
Journal Article

Summary
Plant survival to a potential plethora of diverse environmental insults is underpinned by coordinated communication amongst organs to help shape effective responses to these environmental challenges at the whole plant level. This interorgan... Read More about Interorgan, intraorgan and interplant communication mediated by nitric oxide and related species.

Effect of morpholino-mediated knockdowns of oncofetal RNA-binding proteins on cancer cell biology (2024)
Thesis

Background: Muscleblind-like 3 (MBNL3) and insulin-like growth factor 2 binding protein 1 (IGF2BP1) are two RNA-binding proteins that are considered oncofetal genes. The cancer cell-specific expression of oncofetal genes suggests a potential therapeu... Read More about Effect of morpholino-mediated knockdowns of oncofetal RNA-binding proteins on cancer cell biology.

Does it run in the family? - Improving radiological risk assessment in the coastal environment using taxonomic and phylogenetic perspectives in macroalgae species (2024)
Journal Article

Marine macroalgae are widely used indicator species for monitoring environmental radioactivity. Empirical studies have demonstrated a range in radionuclide transfer coefficients, or concentration ratios (CRs), between taxonomic groups, however the CR... Read More about Does it run in the family? - Improving radiological risk assessment in the coastal environment using taxonomic and phylogenetic perspectives in macroalgae species.

Lessons learnt from the implementation of the Covid-19 vaccination programme in the Southwest of England (2024)
Journal Article

Background
Vaccination remains one of the most successful public health interventions in preventing severe disease and death. The roll-out of Covid-19 vaccination programmes has helped protect billions of people around the world against Covid-19. Mo... Read More about Lessons learnt from the implementation of the Covid-19 vaccination programme in the Southwest of England.

Re-establishing historic ecosystem links through targeted species reintroduction: Beaver-mediated wetlands support increased bat activity (2024)
Journal Article

Despite the global significance of wetlands, conservation strategies often fall short in preserving these ecosystems due to failures in incorporating processes that sustain the ecosystem functioning, hydrological dynamics, ecological processes, and b... Read More about Re-establishing historic ecosystem links through targeted species reintroduction: Beaver-mediated wetlands support increased bat activity.

Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype (2024)
Journal Article

The genetic background of the high prevalence red blood cell antigen AnWj has remained unresolved since its identification in 1972, despite reported associations with both CD44 and Smyd1 histone methyltransferase. Development of anti-AnWj, which may... Read More about Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype.

A study into the biological activity and therapeutic potential of molecular hydrogen and oxyhydrogen gases (2024)
Thesis

Molecular hydrogen (H2) and oxyhydrogen (66% H2/ 33% O2) gases can remediate the effects of numerous diseases in adults. By acting as an anti-inflammatory and antioxidative agent, it is reported that H2 administration can improve recovery through mi... Read More about A study into the biological activity and therapeutic potential of molecular hydrogen and oxyhydrogen gases.

Development of biological recognition elements for the detection of the genome of cocoa swollen shoot virus (2024)
Thesis

Cacao swollen shoot virus (CSSV) is the main threat to chocolate production in West Africa. Infection causes a decrease in bean production yield and can cause tree death within three years, causing socio-economic damage to small-holding farmers.

C... Read More about Development of biological recognition elements for the detection of the genome of cocoa swollen shoot virus.

Impact of cold atmospheric plasma pretreatment on the recovery of phenolic antioxidants from spent coffee grounds (2024)
Journal Article

In the present study, cold atmospheric plasma (CAP) was employed as a pretreatment method for the extraction of phenolic compounds from spent coffee grounds (SCGs). The impact of CAP treatment conditions, i.e., thickness of the SCGs layer (mm), dista... Read More about Impact of cold atmospheric plasma pretreatment on the recovery of phenolic antioxidants from spent coffee grounds.