Role of splice variants in the metastatic progression of prostate cancer

Hagen, Rachel M.; Ladomery, Michael

Abstract

AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately altering metastatic potential. As metastases are the cause of approximately 90% of all human cancer deaths, it is crucial to understand how AS is dysregulated in metastatic disease. We highlight some recent studies into the relationship between altered AS of key genes and the initiation of prostate cancer metastasis. ©The Authors Journal compilation ©2012 Biochemical Society.

• Presentation Conference Type: Conference Paper (published)
• Publication Date: Aug 1, 2012
• Deposit Date: Oct 19, 2012
• Publicly Available Date: Nov 15, 2016
• Journal: Biochemical Society Transactions
• Print ISSN: 0300-5127
• Electronic ISSN: 1470-8752
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 4
• Pages: 870-874
• DOI: https://doi.org/10.1042/BST20120026
• Keywords: alternative splicing, central alternative exon, epidermal growth factor, metastasis, prolactin, prostate cancer
• Public URL: https://uwe-repository.worktribe.com/output/953280
• Publisher URL: http://dx.doi.org/10.1042/BST20120026
• Additional Information: Additional Information : This is a review article
• Contract Date: Nov 15, 2016