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The emerging role of lysophosphatidic acid (LPA) in skeletal biology

Blackburn, Julia; Mansell, Jason Peter


Julia Blackburn

Jason Mansell
Associate Professor in Biomedical Sciences


Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most mammalian cell types. Although LPA has an established role in many biological processes, particularly wound healing and cancer, the participation of LPA in skeletal biology is just beginning to emerge. Early studies, identified in this review, gave a solid indication that LPA, via binding to one of several cell surface receptors, activated multiple intracellular systems culminating in altered cell morphology, growth, motility and survival. More recently the ablation of murine LPA1 and 4 receptors implies that this lipid has a role in skeletal development and post natal bone accrual. Greater understanding of the ability of LPA to influence, for example, osteoblast growth, maturation and survival could be advantageous in developing novel strategies aimed at improving skeletal tissue repair and regeneration. Herein this review provides an insight into the diversity of studies exploring the actions of a small lipid on those major cell types key to skeletal tissue health and homeostasis. © 2011 Elsevier Inc.


Mansell, J. P., Blackburn, J., & Mansell, J. P. (2012). The emerging role of lysophosphatidic acid (LPA) in skeletal biology. BONE, 50(3), 756-762.

Journal Article Type Review
Publication Date Mar 1, 2012
Journal Bone
Print ISSN 8756-3282
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 50
Issue 3
Pages 756-762
Keywords lysophosphatidic acid, LPA receptors, LPA signalling, skeletal cells, osteogenesis
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