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Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs

Marriott, Duncan T.; Chevillon, Patrick; Spencer-Phillips, Peter T.N.; Doran, Olena


Duncan T. Marriott

Patrick Chevillon

Olena Doran
College Dean of Research and Enterprise


This study investigated the role of lipogenic enzyme expression in breed-specific fat deposition in pigs. Objectives: (i) determine effect of breed on the relative abundance of the key lipogenic enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (Δ6D), and fatty acid synthase (FAS) in pig subcutaneous adipose tissue. (ii) Investigate breed-specific relationships between lipogenic enzyme abundance and fatty acid composition. Large White × Piétrain, Piétrain, and Duroc × Piétrain pigs were used. Expression of SCD, Δ6D, and FAS was analyzed by Western blotting. Fatty acid composition was determined by gas chromatography. FAS protein in Large White × Piétrain pigs was similar to the Piétrain breed, but was significantly higher than Duroc × Piétrain. A positive relationship was found between FAS abundance and the saturated fatty acids (SFAs), for Large White × Piétrain pigs, but not for the other breeds. Δ6D was significantly higher in Large White × Piétrain compared with Duroc × Piétrain and Piétrain. This was accompanied by significantly higher total n-3 poly-unsaturated fatty acids (PUFAs) in the Large White × Piétrain when compared to the other breeds. Conclusions: (i) increased subcutaneous adipose tissue SFA content in Large White × Piétrain pigs (but not Piétrain and Duroc × Piétrain) is related to increased abundance of FAS protein; (ii) high n-3 PUFA content in Large White × Piétrain pigs is related to activation of Δ6D protein synthesis; (iii) SCD and Δ6D abundance does not contribute to between-breed differences in MUFA and n-6 PUFA content of pig subcutaneous adipose tissue. © 2013 Institute of Food Technologists®.


Marriott, D. T., Chevillon, P., Spencer-Phillips, P. T., & Doran, O. (2013). Effect of breed on fatty acid composition and lipogenic enzyme abundance in the subcutaneous adipose tissue of pigs. Journal of Food Science, 78(8), C1130-C1135.

Journal Article Type Article
Publication Date Aug 1, 2013
Journal Journal of Food Science
Print ISSN 0022-1147
Electronic ISSN 1750-3841
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 78
Issue 8
Pages C1130-C1135
Keywords breed, fatty acid composition, lipogenic enzymes, pig, protein abundance, subcutaneous fat
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