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Genomic diversity of bacteriophages infecting the genus acinetobacter

Oliveira, Hugo; Domingues, Rita; Evans, Benjamin; Sutton, J. Mark; Adriaenssens, Evelien M.; Turner, Dann

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Authors

Hugo Oliveira

Rita Domingues

Benjamin Evans

J. Mark Sutton

Evelien M. Adriaenssens



Abstract

The number of sequenced Acinetobacter phage genomes in the International Nucleotide Sequence Database Collaboration has increased significantly in recent years, from 37 in 2017 to a total of 139 as of January 2021 with genome sizes ranging from 31 to 378 kb. Here, we explored the genetic diversity of the Acinetobacter phages using comparative genomics approaches that included assessment of nucleotide similarity, shared gene content, single gene phylogeny, and the network-based classification tool vConTACT2. Phages infecting Acinetobacter sp. are genetically diverse and can be grouped into 8 clusters (subfamilies) and 46 sub-clusters (genera), of which 8 represent genomic singletons (additional genera). We propose the creation of five new subfamilies and suggest a reorganisation of the genus Obolenskvirus. These results provide an updated view of the viruses infecting Acinetobacter species, providing insights into their diversity.

Citation

Oliveira, H., Domingues, R., Evans, B., Sutton, J. M., Adriaenssens, E. M., & Turner, D. (2022). Genomic diversity of bacteriophages infecting the genus acinetobacter. Viruses, 14(2), Article 181. https://doi.org/10.3390/v14020181

Journal Article Type Article
Acceptance Date Jan 10, 2022
Online Publication Date Jan 19, 2022
Publication Date Jan 19, 2022
Deposit Date Feb 24, 2022
Publicly Available Date Feb 24, 2022
Journal Viruses
Electronic ISSN 1999-4915
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 14
Issue 2
Article Number 181
DOI https://doi.org/10.3390/v14020181
Keywords Virology; Infectious Diseases; Acinetobacter; bacteriophages; comparative genomics; phage therapy; bioinformatics
Public URL https://uwe-repository.worktribe.com/output/8809667
Publisher URL https://www.mdpi.com/journal/viruses

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