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Cellular redox environment and its influence on redox signalling molecules

Hancock, John T; Whiteman, Matthew


Matthew Whiteman


The redox potential of a cell’s internal environment is well recognised as important for controlling cellular activities. Both animal and plant cells generate and are exposed to a range of reactive molecules involved in cell signalling, including reactive oxygen species and reactive nitrogen species, such as hydrogen peroxide and nitric oxide. Redox active molecules exist in different oxidation states, with the ratio of the states being able to be determined using the Nernst equation. Therefore influence of redox environments of cells on the likelihood of the persistence of a particular redox state of a molecule can be estimated, and this might have a profound effect on whether molecules can act as signals. Although the cellular redox may have little influence on some molecules, for others there may be a significant impact from the redox environment. Furthermore, cellular redox environments fluctuate and as they become more oxidising some signalling molecules may become more persistent while the moderating effect of others may be lessened. Such influence of redox environment needs to be taken into account if the role of such molecules in cell signalling is to be understood.


Hancock, J. T., & Whiteman, M. (2018). Cellular redox environment and its influence on redox signalling molecules

Journal Article Type Article
Acceptance Date Dec 17, 2017
Publication Date Jan 1, 2018
Journal Reactive Oxygen Species
Peer Reviewed Peer Reviewed
Volume 5
Issue 14
Keywords redox, glutathione, reactive oxygen species, nitric oxide, cell signalling
Publisher URL


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