Skip to main content

Research Repository

Advanced Search

The development of the ICIQ-UAB: A patient reported outcome measure for underactive bladder

Uren, Alan D.; Cotterill, Nikki; Harding, Christopher; Hillary, Christopher; Chapple, Christopher; Lasch, Kathryn; Stroupe, Angela; Deshpande, Chinmay; Delbecque, Laure; Van Koeveringe, Gommert; Oelke, Matthias; Belal, Mohammed; Bosch, Ruud; Blok, Bertil; Nitti, Victor; Gotoh, Momokazu; Takei, Mineo; Crawford, Bruce; Klaver, Monique; Bongaerts, Dominique; Hakimi, Zalmai; Kos, Ton; Abrams, Paul

The development of the ICIQ-UAB: A patient reported outcome measure for underactive bladder Thumbnail


Authors

Alan D. Uren

Profile image of Nikki Cotterill

N Nikki Cotterill Nikki.Cotterill@uwe.ac.uk
Professor of Long Term Conditions (Continence Care)

Christopher Harding

Christopher Hillary

Christopher Chapple

Kathryn Lasch

Angela Stroupe

Chinmay Deshpande

Laure Delbecque

Gommert Van Koeveringe

Matthias Oelke

Mohammed Belal

Ruud Bosch

Bertil Blok

Victor Nitti

Momokazu Gotoh

Mineo Takei

Bruce Crawford

Monique Klaver

Dominique Bongaerts

Zalmai Hakimi

Ton Kos

Paul Abrams



Abstract

Aims: To present the development of the International Consultation on Incontinence Questionnaire-underactive bladder (ICIQ-UAB) as the first patient reported outcome measure for the assessment of the symptoms and impact on the health-related quality of life of UAB developed in-line with the Food and Drug Administration Guidance for Industry.

Methods: Draft items were developed following 44 semi-structured concept elicitation interviews in the UK and refined using 36 cognitive interviews. A pilot study was designed to assess the draft ICIQ-UAB's initial psychometric properties with 54 patients recruited from European hospitals. Further concept elicitation interviews were also carried out with 11 patients in the US and 10 patients in Japan. All participants had a prior urodynamic diagnosis of detrusor underactivity.

Results: The cognitive interviews confirmed the initial items to be understood and interpreted as intended. Pilot testing showed that both internal consistency (Cronbach's α ≥ 0.85) and test-retest reliability (stable patients; intraclass correlation coefficient ≥ 0.88) werehigh. The interviews in the US and Japan elicited symptoms and impacts that support previous findings in the UK and provided further insight into the experiences of patients in those countries. The developmental ICIQ-UAB was refined using the evidence from all substudies.

Conclusions: The validity and reliability of the ICIQ-UAB were supported in a pilot study settingand the wider cultural applicability by the additional interviews in the US and Japan. Following further validation in future clinical trials, the developmental ICIQ-UAB is envisaged as an important tool for the monitoring of future UAB treatment strategies.

Journal Article Type Article
Acceptance Date Jan 24, 2019
Online Publication Date Feb 22, 2019
Publication Date Mar 23, 2019
Deposit Date Jul 17, 2018
Publicly Available Date Feb 23, 2020
Journal Neurourology and Urodynamics
Print ISSN 0733-2467
Electronic ISSN 1520-6777
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 38
Issue 3
Pages 996-1004
DOI https://doi.org/10.1002/nau.23947
Keywords detrusor underactivity, patient reported outcomes, qualitative, quality of life, underactive bladder
Public URL https://uwe-repository.worktribe.com/output/865821
Contract Date Jul 17, 2018

Files

ICIQ-UAB manuscript N and U FINAL 10 07 18 with tables and figures.pdf (1.5 Mb)
PDF

Licence
http://www.rioxx.net/licenses/all-rights-reserved

Publisher Licence URL
http://www.rioxx.net/licenses/all-rights-reserved

Copyright Statement
This is the peer reviewed version of the following article: Uren, A., Cotterill, N., Harding, C., et al (2019). The development of the ICIQ-UAB: A patient reported outcome measure for underactive bladder. Neurourology and Urodynamics, which has been published in final form at https://doi.org/10.1002/nau.23947. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving


ICIQ-UAB manuscript N and U FINAL 10 07 18 with tables and figures.docx (306 Kb)
Document

Licence
http://www.rioxx.net/licenses/all-rights-reserved

Publisher Licence URL
http://www.rioxx.net/licenses/all-rights-reserved

Copyright Statement
This is the peer reviewed version of the following article: Uren, A., Cotterill, N., Harding, C., et al (2019). The development of the ICIQ-UAB: A patient reported outcome measure for underactive bladder. Neurourology and Urodynamics, which has been published in final form at https://doi.org/10.1002/nau.23947. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving






You might also like



Downloadable Citations