Evolving Boolean regulatory networks with epigenetic control

Bull, Larry

Abstract

The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness. © 2013 Elsevier Ireland Ltd.

• Journal Article Type: Article
• Publication Date: Feb 1, 2014
• Deposit Date: Jun 17, 2015
• Publicly Available Date: Nov 15, 2016
• Journal: BioSystems
• Print ISSN: 0303-2647
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 116
• Issue: 1
• Pages: 36-42
• DOI: https://doi.org/10.1016/j.biosystems.2013.12.004
• Keywords: evolution, Boolean
• Public URL: https://uwe-repository.worktribe.com/output/821447
• Publisher URL: http://dx.doi.org/10.1016/j.biosystems.2013.12.004
• Additional Information: Additional Information : © 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
• Contract Date: Nov 15, 2016