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Evolving Boolean regulatory networks with epigenetic control

Bull, Larry

Authors

Lawrence Bull Larry.Bull@uwe.ac.uk
AHOD Research and Scholarship and Prof



Abstract

The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness.

Journal Article Type Article
Publication Date Feb 1, 2014
Journal Biosystems
Print ISSN 0303-2647
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 116
Pages 36-42
APA6 Citation Bull, L. (2014). Evolving Boolean regulatory networks with epigenetic control. BioSystems, 116, 36-42. https://doi.org/10.1016/j.biosystems.2013.12.004
DOI https://doi.org/10.1016/j.biosystems.2013.12.004
Keywords evolution, Boolean
Publisher URL http://dx.doi.org/10.1016/j.biosystems.2013.12.004
Additional Information Additional Information : © 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

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