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Evolving Boolean regulatory networks with epigenetic control

Bull, Larry

Evolving Boolean regulatory networks with epigenetic control Thumbnail


Lawrence Bull
School Director (Research & Enterprise) and Professor


The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness. © 2013 Elsevier Ireland Ltd.


Bull, L. (2014). Evolving Boolean regulatory networks with epigenetic control. BioSystems, 116(1), 36-42.

Journal Article Type Article
Publication Date Feb 1, 2014
Deposit Date Jun 17, 2015
Publicly Available Date Nov 15, 2016
Journal BioSystems
Print ISSN 0303-2647
Electronic ISSN 1872-8324
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 116
Issue 1
Pages 36-42
Keywords evolution, Boolean
Public URL
Publisher URL
Additional Information Additional Information : © 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


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