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Evolving Boolean regulatory networks with epigenetic control

Bull, Larry


Lawrence Bull
AHOD Research and Scholarship and Prof


The significant role of epigenetic mechanisms within natural systems has become increasingly clear. This paper uses a recently presented abstract, tunable Boolean genetic regulatory network model to explore aspects of epigenetics. It is shown how dynamically controlling transcription via a DNA methylation-inspired mechanism can be selected for by simulated evolution under various single and multicellular scenarios. Further, it is shown that the effects of such control can be inherited without detriment to fitness.


Bull, L. (2014). Evolving Boolean regulatory networks with epigenetic control. BioSystems, 116, 36-42.

Journal Article Type Article
Publication Date Feb 1, 2014
Journal Biosystems
Print ISSN 0303-2647
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 116
Pages 36-42
Keywords evolution, Boolean
Public URL
Publisher URL
Additional Information Additional Information : © 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International


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