Short- and long-term effects of a dentifrice containing dual zinc plus arginine on intra-oral halitosis: Improvements in breath quality

Saad, Saliha; Fitzgerald, Michael; Hewett, Keith; Greenman, John; Vandeven, Mark; Trivedi, Harsh; Masters, James

Abstract

Objectives: These studies aimed to assess the short-term (12-hour, single use) and long-term (four weeks, continuous use) efficacy of a new Dual Zinc plus Arginine dentifrice against intra-oral halitosis versus a negative control.

Methods: Two clinical studies were conducted to assess the dentifrice: a four-week, continuous use parallel design versus a negative control and a single use crossover design versus a negative control. Both studies used organoleptic and hedonic odor judge scores measured 12 hours overnight after product use as the primary efficacy variable. Additionally, the single use study employed SIFT-MS to quantify the intra-oral concentration of volatile sulfur compounds as a complementary measure of efficacy.

Results: In both studies, the Dual Zinc plus Arginine dentifrice provided statistically significant improvements in breath quality across all measures versus a negative control.

Conclusions: Improvements in breath quality were attributed to the effects of zinc cations delivered by the uniquely formulated dentifrice.

Citation

Saad, S., Fitzgerald, M., Hewett, K., Greenman, J., Vandeven, M., Trivedi, H., & Masters, J. (2018). Short- and long-term effects of a dentifrice containing dual zinc plus arginine on intra-oral halitosis: Improvements in breath quality. Journal of Clinical Dentistry, 29(3 (Special Issue A)), 46-54

• Journal Article Type: Article
• Acceptance Date: Feb 1, 2018
• Online Publication Date: Sep 1, 2018
• Publication Date: Sep 1, 2018
• Deposit Date: Feb 20, 2020
• Journal: Journal of Clinical Dentistry
• Print ISSN: 0895-8831
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 3 (Special Issue A)
• Pages: 46-54
• Keywords: arginine; clinical study; dentifrice; intra-oral halitosis; zinc
• Public URL: https://uwe-repository.worktribe.com/output/5464239
• Publisher URL: http://www.jclindent.com/index2.html