Skip to main content

Research Repository

Advanced Search

Short- and long-term effects of a dentifrice containing dual zinc plus arginine on intra-oral halitosis: Improvements in breath quality

Saad, Saliha; Fitzgerald, Michael; Hewett, Keith; Greenman, John; Vandeven, Mark; Trivedi, Harsh; Masters, James

Authors

Saliha Saad Saliha.Saad@uwe.ac.uk
Associate Professor in Biomedical Sciences

Michael Fitzgerald

Keith Hewett

Mark Vandeven

Harsh Trivedi

James Masters



Abstract

Objectives: These studies aimed to assess the short-term (12-hour, single use) and long-term (four weeks, continuous use) efficacy of a new Dual Zinc plus Arginine dentifrice against intra-oral halitosis versus a negative control.

Methods: Two clinical studies were conducted to assess the dentifrice: a four-week, continuous use parallel design versus a negative control and a single use crossover design versus a negative control. Both studies used organoleptic and hedonic odor judge scores measured 12 hours overnight after product use as the primary efficacy variable. Additionally, the single use study employed SIFT-MS to quantify the intra-oral concentration of volatile sulfur compounds as a complementary measure of efficacy.

Results: In both studies, the Dual Zinc plus Arginine dentifrice provided statistically significant improvements in breath quality across all measures versus a negative control.

Conclusions: Improvements in breath quality were attributed to the effects of zinc cations delivered by the uniquely formulated dentifrice.

Journal Article Type Article
Acceptance Date Feb 1, 2018
Online Publication Date Sep 1, 2018
Publication Date Sep 1, 2018
Deposit Date Feb 20, 2020
Journal Journal of Clinical Dentistry
Print ISSN 0895-8831
Peer Reviewed Peer Reviewed
Volume 29
Issue 3 (Special Issue A)
Pages 46-54
Keywords arginine; clinical study; dentifrice; intra-oral halitosis; zinc
Public URL https://uwe-repository.worktribe.com/output/5464239
Publisher URL http://www.jclindent.com/index2.html