Short- and long-term effects of a dentifrice containing dual zinc plus arginine on intra-oral halitosis: Improvements in breath quality

Saad, Saliha; Fitzgerald, Michael; Hewett, Keith; Greenman, John; Vandeven, Mark; Trivedi, Harsh; Masters, James

Abstract

Objectives: These studies aimed to assess the short-term (12-hour, single use) and long-term (four weeks, continuous use) efficacy of a new Dual Zinc plus Arginine dentifrice against intra-oral halitosis versus a negative control.

Methods: Two clinical studies were conducted to assess the dentifrice: a four-week, continuous use parallel design versus a negative control and a single use crossover design versus a negative control. Both studies used organoleptic and hedonic odor judge scores measured 12 hours overnight after product use as the primary efficacy variable. Additionally, the single use study employed SIFT-MS to quantify the intra-oral concentration of volatile sulfur compounds as a complementary measure of efficacy.

Results: In both studies, the Dual Zinc plus Arginine dentifrice provided statistically significant improvements in breath quality across all measures versus a negative control.

Conclusions: Improvements in breath quality were attributed to the effects of zinc cations delivered by the uniquely formulated dentifrice.

• Journal Article Type: Article
• Acceptance Date: Feb 1, 2018
• Online Publication Date: Sep 1, 2018
• Publication Date: Sep 1, 2018
• Deposit Date: Feb 20, 2020
• Journal: Journal of Clinical Dentistry
• Print ISSN: 0895-8831
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 3 (Special Issue A)
• Pages: 46-54
• Keywords: arginine; clinical study; dentifrice; intra-oral halitosis; zinc
• Public URL: https://uwe-repository.worktribe.com/output/5464239
• Publisher URL: http://www.jclindent.com/index2.html