Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation

Craig, Tim J.; Jaafari, Nadia; Petrovic, Milos M.; Rubin, Philip P.; Mellor, Jack R.; Henley, Jeremy M.

Abstract

Background: SUMOylation regulates many cell pathways.
Results: Synaptic scaling elicited by suppression of neuronal activity decreases the deSUMOylating enzyme SENP1; overexpression of SENP1 prevents synaptic scaling.
Conclusion: SUMOylation is required for AMPA receptor trafficking underlying scaling, an important form of neuronal
plasticity.
Significance: Regulation of synaptic dynamics and plasticity is fundamental to understanding brain function and dysfunction

• Journal Article Type: Article
• Online Publication Date: May 11, 2012
• Publication Date: Jun 29, 2012
• Deposit Date: Nov 7, 2024
• Journal: Journal of Biological Chemistry
• Print ISSN: 0021-9258
• Electronic ISSN: 1083-351X
• Publisher: American Society for Biochemistry and Molecular Biology
• Peer Reviewed: Peer Reviewed
• Volume: 287
• Issue: 27
• Pages: 22781-22788
• DOI: https://doi.org/10.1074/jbc.m112.356337
• Public URL: https://uwe-repository.worktribe.com/output/13406215