Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Williams, Katherine; Szwalbe, Agnieszka J; Dickson, Claire; Desson, Tim R; Mulholland, Nicholas P; Vincent, Jason L; Clough, John M; Bailey, Andrew M; Butts, Craig P; Willis, Christine L; Simpson, Thomas J; Cox, Russell J

Abstract

The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.

• Journal Article Type: Article
• Online Publication Date: Jun 23, 2017
• Publication Date: Jun 23, 2017
• Deposit Date: Apr 11, 2024
• Publicly Available Date: Apr 12, 2024
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 53
• Issue: 56
• Pages: 7965-7968
• DOI: https://doi.org/10.1039/c7cc03303f
• Public URL: https://uwe-repository.worktribe.com/output/11881312
• Publisher URL: http://dx.doi.org/10.1039/c7cc03303f