Agnieszka J Szwalbe
Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi
Szwalbe, Agnieszka J; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate; Vincent, Jason L; Bailey, Andrew M; Willis, Christine L; Cox, Russell J; Simpson, Thomas J
Authors
Katherine Williams
Zhongshu Song
Kate De Mattos-Shipley
Jason L Vincent
Andrew M Bailey
Christine L Willis
Russell J Cox
Thomas J Simpson
Abstract
Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crystallography. The agnestin (agn) biosynthetic gene cluster was identified and targeted gene disruptions of the PKS, Baeyer-Villiger monooxygenase, and other oxido-reductase genes revealed new details of fungal xanthone biosynthesis. In particular, identification of a reductase responsible for in vivo anthraquinone to anthrol conversion confirms a previously postulated essential step in aromatic deoxygenation of anthraquinones, e.g. emodin to chrysophanol.
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 23, 2018 |
Online Publication Date | Nov 26, 2018 |
Publication Date | Nov 26, 2018 |
Deposit Date | Apr 10, 2024 |
Publicly Available Date | Apr 10, 2024 |
Journal | Chemical Science |
Print ISSN | 2041-6520 |
Electronic ISSN | 2041-6539 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 1 |
Pages | 233-238 |
DOI | https://doi.org/10.1039/C8SC03778G |
Keywords | Synthetic Biology |
Public URL | https://uwe-repository.worktribe.com/output/11881298 |
Publisher URL | http://dx.doi.org/10.1039/C8SC03778G |
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Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi
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Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
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