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A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia

Oliver, Cerys; Li, Haoxuan; Biswas, Bijetri; Woodstoke, David; Blackman, Jonathan; Butters, Anneka; Drew, Cheney; Gabb, Victoria; Harding, Sam; Hoyos, Camilla M; Kendrick, Adrian; Rudd, Sarah; Turner, Nicholas; Coulthard, Elizabeth

A systematic review on adherence to continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in individuals with mild cognitive impairment and Alzheimer's disease dementia Thumbnail


Authors

Cerys Oliver

Haoxuan Li

Bijetri Biswas

David Woodstoke

Jonathan Blackman

Anneka Butters

Cheney Drew

Victoria Gabb

Sam Harding

Camilla M Hoyos

Profile image of Adrian Kendrick

Dr Adrian Kendrick Adrian.Kendrick@uwe.ac.uk
Senior Lecturer in Physiological Science (Respiratory/Sleep)

Sarah Rudd

Nicholas Turner

Elizabeth Coulthard



Abstract

Obstructive sleep apnoea (OSA) is highly prevalent in mild cognitive impairment (MCI) and Alzheimer's disease (AD). The gold standard treatment for OSA is continuous positive airway pressure (CPAP). Long-term, well-powered efficacy trials are required to understand whether CPAP could slow cognitive decline in individuals with MCI/AD, but its tolerability in this group remains uncertain. The present review investigates CPAP adherence among individuals with OSA and MCI/AD. Electronic searches were performed on 8 databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Six independent studies and four secondary analyses included 278 unique participants (mean age = 72.1 years). In five of the retained studies, around half of participants (45% N = 85 MCI, 56% N = 22 AD) were adherent to CPAP, where ≥4 h use per night was considered adherent. Three of the retained studies also reported average CPAP use to range between 3.2 and 6.3 h/night. CPAP adherence in individuals with MCI and AD is low, albeit similar to the general elderly population. Reporting adherence in future studies as both average duration as well as using a binary cut-off would improve our understanding of the optimum CPAP use in dementia clinical trials and care.

Journal Article Type Article
Acceptance Date Oct 16, 2023
Online Publication Date Oct 24, 2023
Publication Date Feb 28, 2024
Deposit Date Mar 12, 2024
Publicly Available Date Mar 12, 2024
Journal Sleep Medicine Reviews
Print ISSN 1087-0792
Electronic ISSN 1532-2955
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 73
Article Number 101869
DOI https://doi.org/10.1016/j.smrv.2023.101869
Keywords Alzheimer’s, Cognitive impairment, Sleep apnoea, Dementia, Continuous positive airway pressure
Public URL https://uwe-repository.worktribe.com/output/11462464

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