Comparing closed-loop control of drug infusion using MPC and PID

Setati, Tiro; Perold, Willem; Fourie, Pieter; Withey, Daniel

Abstract

Continuous intravenous drug delivery can require careful dosage and the maintenance of consistent blood plasma concentration levels. Here, the closed-loop control of drug concentration in simulated patients’ bloodstreams was investigated. During the investigation, the closed-loop controller performance of a Proportional-Integral-Derivative (PID) and a Model Predictive Controller (MPC) were compared. From the simulation results, the MPC has shown to be a better controller because of its shorter settling time and smaller stepresponse overshoot, which are desirable in a clinical setting. However, the MPC has shown to be more resource-intensive on the controller system. Through the simulations conducted, it can therefore be concluded that a closed-loop controller containing an MPC control block adequately controls the drug infusion to a simulated patient.

• Presentation Conference Type: Conference Paper (published)
• Conference Name: 15th International Conference on Biomedical Electronics and Devices
• Start Date: Feb 9, 2022
• End Date: Feb 11, 2022
• Acceptance Date: Nov 15, 2021
• Publication Date: 2022
• Deposit Date: Jan 12, 2023
• Publicly Available Date: Jan 23, 2023
• Pages: 126-133
• Book Title: Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies - BIODEVICES
• DOI: https://doi.org/10.5220/0010783700003123
• Keywords: Control Systems, Model-Predictive Controller (MPC), Proportional-Integral-Derivative (PID) Controller, Anesthesia, Intravenous Infusion
• Public URL: https://uwe-repository.worktribe.com/output/10339107
• Publisher URL: https://www.scitepress.org/Link.aspx?doi=10.5220/0010783700003123