Modern chemotherapeutic regimens for adult and childhood leukaemia rely on the use of a combination of various cytotoxic agents. Unfortunately, haematopoietic stem cell transplant, a last resort treatment for haematologic malignancies requires high d... Read More about Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment.
APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps (2020)
Journal Article
Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and hyper... Read More about APC and AXIN2 are promising biomarker candidates for the early detection of adenomas and hyperplastic polyps.
The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients (2018)
Journal Article
A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes-information which is also important in assessing any possibilities of lymph node resection so as to i... Read More about The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients.
GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients (2018)
Journal Article
Lymphedema is a condition resulting from mutations in various genes essential for lymphatic development and function, which leads to obstruction of the lymphatic system. Secondary lymphedema is a progressive and incurable condition, most often manife... Read More about GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients.
An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck (2014)
Journal Article
© 2014 Elsevier Ireland Ltd. The Tudor warship the Mary Rose sank in the Solent waters between Portsmouth and the Isle of Wight on the 19th of July 1545, whilst engaging a French invasion fleet. The ship was rediscovered in 1971 and between 1979 and... Read More about An old dog and new tricks: Genetic analysis of a Tudor dog recovered from the Mary Rose wreck.
Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations (2009)
Journal Article
Killer cell immunoglobulin-like receptors (KIR) gene frequencies vary between populations and contribute to functional variation in immune responses to viruses, autoimmunity and reproductive success. This study describes the frequency distribution of... Read More about Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.