Outputs (6)

Identifying targetable metabolic dependencies across colorectal cancer progression (2024)
Journal Article

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet... Read More about Identifying targetable metabolic dependencies across colorectal cancer progression.

Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways (2024)
Journal Article

Approximately 50% of poor prognosis neuroblastomas arise due to MYCN over-expression. We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 knockdown led to apoptosis of MYCN amplified (MNA) neuroblastoma. Here we evaluate the hi... Read More about Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

The effects of glucose supplementation on the development of Acinetobacter baumannii biofilms (2024)
Presentation / Conference Contribution

The Effect of Glucose on The Development of Acinetobacter baumannii Biofilm

Background: Acinetobacter baumannii, is an opportunistic pathogen causing pneumonia, bacteraemia, wound and urinary tract infections with high mortality rates due to multi... Read More about The effects of glucose supplementation on the development of Acinetobacter baumannii biofilms.

Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii (2024)
Journal Article

Introduction . Acinetobacter baumannii is a critical priority pathogen for novel antimicrobials (World Health Organization) because of the rise in nosocomial infections and its ability to evolve resistance to last resort antibiotics. A. baumannii is... Read More about Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii.

Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons (2024)
Journal Article

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway... Read More about Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.

In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy (2024)
Journal Article

Infections caused by Pseudomonas aeruginosa are becoming increasingly difficult to treat due to the emergence of strains that have acquired multidrug resistance. Therefore, phage therapy has gained attention as an alternative to the treatment of pseu... Read More about In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy.