Outputs (39)
Validation of a sensor system for the measurement of breath ammonia using selected-ion flow-tube mass spectrometry (2024)
Journal Article
The measurement of trace breath gases is of growing interest for its potential to provide non-invasive physiological information in health and disease. While instrumental techniques such as selected-ion flow-tube mass spectrometry (SIFT-MS) can achie... Read More about Validation of a sensor system for the measurement of breath ammonia using selected-ion flow-tube mass spectrometry.
Identifying targetable metabolic dependencies across colorectal cancer progression (2024)
Journal Article
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet... Read More about Identifying targetable metabolic dependencies across colorectal cancer progression.
Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways (2024)
Journal Article
Approximately 50% of poor prognosis neuroblastomas arise due to MYCN over-expression. We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 knockdown led to apoptosis of MYCN amplified (MNA) neuroblastoma. Here we evaluate the hi... Read More about Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.
Video gaming and sleep in adults: A systematic review (2024)
Journal Article
Video games (VGs) are one of the most common forms of entertainment and their diffusion is constantly increasing. Although largely studied in the framework of their relationship with mental and physical health, the relationship of VGs with sleep are... Read More about Video gaming and sleep in adults: A systematic review.
The peer review process: Past, present, and future (2024)
Journal Article
The peer review process is a fundamental aspect of modern scientific paper publishing, underpinning essential quality control. First conceptualised in the 1700s, it is an iterative process that aims to elevate scientific literature to the highest sta... Read More about The peer review process: Past, present, and future.
Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review (2024)
Journal Article
Background Healthcare associated infections (HAIs) are a major threat to patient safety and quality care. However, they are avoidable by implementing evidence-based infection prevention and control measures. This re... Read More about Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review.
Editorial: The RNA revolution and cancer (2024)
Journal Article
RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Proces... Read More about Editorial: The RNA revolution and cancer.
Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article
Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.
Quantifying the microstructural and biomechanical changes in the porcine ventricles during growth and remodelling (2023)
Journal Article
Cardiac tissue growth and remodelling (G & R) occur in response to the changing physiological demands of the heart after birth. The early shift to pulmonary circulation produces an immediate increase in ventricular workload, causing microstructural a... Read More about Quantifying the microstructural and biomechanical changes in the porcine ventricles during growth and remodelling.
Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article
To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..
Dual wavelength retinal vessel oximetry – influence of fundus pigmentation (2022)
Journal Article
Background: Clinical methods examining oxygenation parameters in humans have been used in many different care settings, but concerns have been raised regarding their clinical utility when assessing people with darker skin pigmentation. While saturati... Read More about Dual wavelength retinal vessel oximetry – influence of fundus pigmentation.
Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia (2022)
Journal Article
Leadership and management skills are critical for health programs to deliver high-quality interventions in complex systems. In malaria-eliminating countries, national and subnational health teams are reorienting strategies to address focal transmissi... Read More about Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia.
Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea (2022)
Journal Article
Bioko is one of the most important sites for African primate conservation; yet it has seen a severe decline in its primate populations due to illegal hunting to supply a thriving wildmeat trade. The completion in 2015 of a new road bisecting the Gran... Read More about Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea.
An on-premise study to investigate the effects of mixing alcohol with caffeinated beverages (2022)
Journal Article
Objective: The purpose of this on-premise study was to determine if mixing alcohol with caffeinated mixers had an impact on objective and subjective intoxication. Methods: The study was conducted across eight drinking occasions in the City of Bristol... Read More about An on-premise study to investigate the effects of mixing alcohol with caffeinated beverages.
A comparison between ecological momentary assessment and the adapted-quick drinking screen: Alcohol mixed with energy drinks (2022)
Journal Article
AIMS: To compare alcohol consumption and risk-taking behaviours on alcohol mixed with energy drink (AMED) and alcohol-only (AO) drinking occasions collected via ecological momentary assessment (EMA) versus retrospective survey methods (adapted-Quick... Read More about A comparison between ecological momentary assessment and the adapted-quick drinking screen: Alcohol mixed with energy drinks.
Accelerometers-embedded Lycra sleeves to test wear compliance and upper limb activity in people with stroke: A feasibility study (2021)
Journal Article
Introduction To establish a possible effect of Lycra sleeves, accurate recording of wear time is critical. The aim of this study was to test whether an accelerometer-embedded Lycra sleeve can measure wear compliance and record upper-limb (UL) movemen... Read More about Accelerometers-embedded Lycra sleeves to test wear compliance and upper limb activity in people with stroke: A feasibility study.
Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article
Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.
CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer (2021)
Journal Article
Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and o... Read More about CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.
Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomized trial (2021)
Journal Article
Background: Effective treatment of longstanding Complex Regional Pain Syndrome (CRPS) is a challenge, as causal mechanisms remain elusive. People with CRPS frequently report distorted subjective perceptions of their affected limb. Evidence of pain re... Read More about Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomized trial.