Problems in the analysis of pharmaceuticals and other basic solutes in HPLC: Some solutions using recently developed columns
(2008)
Presentation / Conference Contribution
Professor David McCalley's Outputs (6)
Investigation of the effect of pressure on retention of small molecules using reversed-phase ultra-high-pressure liquid chromatography (2008)
Journal Article
The effect of inlet pressure on the retention of a series of low molecular weight acids, bases and neutrals, was investigated at constant temperature in reversed-phase liquid chromatography using a commercial ultra-high-pressure system (Waters UPLC i... Read More about Investigation of the effect of pressure on retention of small molecules using reversed-phase ultra-high-pressure liquid chromatography.
Evaluation of the properties of a superficially porous silica stationary phase in hydrophilic interaction chromatography (2008)
Journal Article
The sample capacity, column efficiency (and its variation with flow) of a superficially porous unbonded silica phase (Halo) was investigated using hydrophilic interaction chromatography (HILIC), particularly for separation of basic compounds. Sample... Read More about Evaluation of the properties of a superficially porous silica stationary phase in hydrophilic interaction chromatography.
Estimation of the extent of the water-rich layer associated with the silica surface in hydrophilic interaction chromatography (2008)
Journal Article
The possible presence of a mobile phase layer rich in water on the surface of silica columns used under conditions typical in hydrophilic interaction chromatography was investigated by the injection of a small hydrophobic solute (benzene) using aceto... Read More about Estimation of the extent of the water-rich layer associated with the silica surface in hydrophilic interaction chromatography.
Superficially porous silica stationary phases in hydrophilic interaction chromatography (2008)
Presentation / Conference Contribution
Analysis of basic compounds by reversed-phase high-performance liquid chromatography using hybrid inorganic/organic phases at high pH (2008)
Journal Article
The retention and mass overload of five bases and a quaternary ammonium compound were studied on a bridged ethyl hybrid inorganic/organic phase (XBridge C18) over a pH range 2.7-12.0 using acetonitrile-phosphate and carbonate buffers. Some comparison... Read More about Analysis of basic compounds by reversed-phase high-performance liquid chromatography using hybrid inorganic/organic phases at high pH.