All Outputs (147)

Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species (2017)
Journal Article

© 2017 Elsevier B.V. Cacao swollen shoot virus is a member of the family Caulimoviridae, genus Badnavirus and is naturally transmitted to Theobroma cacao (L.) by several mealybug species. CSSV populations in West African countries are highly variable... Read More about Next generation sequencing elucidates cacao badnavirus diversity and reveals the existence of more than ten viral species.

Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances (2017)
Journal Article

© 2017 Hartill, Szymanska, Sharif, Wheway and Johnson. Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary... Read More about Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances.

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity (2017)
Journal Article

© The Author(s) named above 2018. Background:LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5 + cells are known to exist outside... Read More about LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity.

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2017)
Journal Article

© 2017 Glutamate is the major excitatory neurotransmitter of the central nervous system, with the branched-chain amino acids (BCAAs) acting as key nitrogen donors for de novo glutamate synthesis. Despite the importance of these major metabolites, the... Read More about Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism.

Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS) (2017)
Presentation / Conference Contribution

Electrochemically activated solutions (ECAS) are of interest as potential disinfectants due to high biocidal activity against many microorganisms. They are widely used clinically in some countries (decontamination of surgical instruments and wounds),... Read More about Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS).

Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor (2017)
Presentation / Conference Contribution

This study aimed to develop a 2D leukaemia-stroma model of the bone marrow for analysis of stromal-mediated chemo-protection; known to contribute to chemotherapy resistance. The model must facilitate integration of a bioluminescent biosensor HA1 for... Read More about Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor.

Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia (2017)
Presentation / Conference Contribution

Treatment success in leukaemia is impacted by patient resistance to chemotherapy including cytarabine (ara-C) and the anthracycline daunorubicin (DNR) requiring rapid pre-screening testing. DNR is converted to daunorubicinol (DNRol) by carbonyl reduc... Read More about Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia.

Hydrogen gas and its role in cell signaling (2017)
Journal Article

Hydrogen gas (H2) was once thought to be inert in biological systems but it has now become apparent that exposure of a wide range of organisms, including animals and plants, to H2 or hydrogen-rich water (HRW) has beneficial effects. It is involved in... Read More about Hydrogen gas and its role in cell signaling.

Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia (2017)
Thesis

Alternative splicing of pre-mRNA is a ubiquitous and versatile mechanism controlling the expression of human genes. In humans, approximately 93% of multi-exonic genes are alternatively spliced, producing functionally distinct proteins. Dysregulation... Read More about Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia.

The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory (2017)
Journal Article

© 2017 The Author(s). Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus. Dentate... Read More about The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory.

Science at the Fringe (2017)
Journal Article

Andrew Glester visits this year's Edinburgh Festival Fringe and seeks out science-themed shows

Effects of High Pressure on Phospholipid Bilayers (2017)
Journal Article

© 2017 American Chemical Society. The response of lipid membranes to changes in external pressure is important for many biological processes, and it can also be exploited for technological applications. In this work, we employ all-atom molecular dyna... Read More about Effects of High Pressure on Phospholipid Bilayers.

The effect of hypoxia on alternative splicing in prostate cancer cell lines (2017)
Thesis

Hypoxia is defined as the state in which the availability or delivery of oxygen is insufficient to meet tissue demand. It occurs particularly in aggressive, fast-growing tumours in which the rate of new blood vessel formation (angiogenesis) cannot ma... Read More about The effect of hypoxia on alternative splicing in prostate cancer cell lines.

A GIS approach to identifying connectivity potential between brown bear (Ursus Arctos) habitat in Northern Greece (2017)
Presentation / Conference Contribution

The brown bear (Ursus arctos) distribution in Greece is divided between two main large populations, one situated in the Pindos Mountain Range (NW Greece) and the other in the Rhodope Mountain Complex (NE Greece). As a result of recent recolonisation,... Read More about A GIS approach to identifying connectivity potential between brown bear (Ursus Arctos) habitat in Northern Greece.

Presenting and investigating the efficacy of an educational interactive mobile application for British Sign Language using hand gesture detection techniques (2017)
Presentation / Conference Contribution

In this paper we present the design and development of a mobile application that assists learners of British Sign Language. The application uses interaction; namely, image recognition of a participant's gestures to give feedback as to the correctness... Read More about Presenting and investigating the efficacy of an educational interactive mobile application for British Sign Language using hand gesture detection techniques.

The effect of listening to Holy Quran recitation on weaning patients receiving mechanical ventilation in the intensive care unit: A pilot study (2017)
Journal Article

Mechanical ventilation (MV) causes high level of stress in hospitalized patients. Weaning is the gradual process of decreasing ventilator support that in turn lead to termination of MV and increased respiratory effort, which may exacerbate symptoms a... Read More about The effect of listening to Holy Quran recitation on weaning patients receiving mechanical ventilation in the intensive care unit: A pilot study.

Development of cultures of the marine sponge Hymeniacidon perleve for genotoxicity assessment using the alkaline comet assay (2017)
Journal Article

© 2017 SETAC Sponges are a potential alternative model species to bivalves in pollution biomonitoring and environmental risk assessment in the aquatic ecosystem. In the present study, a novel in vivo exposure sponge culture model was developed from f... Read More about Development of cultures of the marine sponge Hymeniacidon perleve for genotoxicity assessment using the alkaline comet assay.

Validation of real-time PCR targeting the ‘Big five’ carbapenemases (2017)
Presentation / Conference Contribution

Poster presentation

Interactive reading using low cost brain computer interfaces (2017)
Presentation / Conference Contribution

This work shows the feasibility for document reader user applications using a consumer grade non-invasive BCI headset. Although Brain Computer Interface (BCI) type devices are beginning to aim at the consumer level, the level at which they can actual... Read More about Interactive reading using low cost brain computer interfaces.

SiP 2017 panel: Speculations and concerns on robots’ status in society (2017)
Journal Article

Studying fictional depictions of robots and artificial intelligence in cinematographic science fiction narratives acquires a new level of relevance as legislators’ approaches to the subject seem to be strongly influenced by popular culture. This pane... Read More about SiP 2017 panel: Speculations and concerns on robots’ status in society.