All Outputs (3)

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors (2008)
Journal Article

Vascular endothelial growth factor A (VEGFA; hereafter referred to as VEGF) is a key regulator of physiological and pathological angiogenesis. Two families of VEGF isoforms are generated by alternate splice-site selection in the terminal exon. Proxim... Read More about Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes (2008)
Journal Article

The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to... Read More about New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.

The post-transcriptional roles of WT1, a multifunctional zinc-finger protein (2008)
Journal Article

WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C2-H2 zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple level... Read More about The post-transcriptional roles of WT1, a multifunctional zinc-finger protein.