All Outputs (3)

Dysfunctional neuronal differentiation links type-2 diabetes and Alzheimer's disease (2025)
Presentation / Conference Contribution

Introduction:
Type 2 diabetes mellitus (T2DM) is one of the most significant risk factors for late-onset Alzheimer’s Disease (LOAD), associated with a nearly 2-fold increase in risk, although the reasons for this are not fully understood. Several re... Read More about Dysfunctional neuronal differentiation links type-2 diabetes and Alzheimer's disease.

Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration (2024)
Journal Article

There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line,... Read More about Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration.

Dysregulation of neuronal differentiation by saturated fatty acids links diet and neurodegeneration (2024)
Presentation / Conference Contribution

Type 2 diabetes mellitus (T2DM) have been associated with a nearly 2-fold increased risk of Alzheimer's disease (AD) development . Recent studies have reported dysregulated hippocampal neurogenesis in AD patients during postmortem examinations. Addit... Read More about Dysregulation of neuronal differentiation by saturated fatty acids links diet and neurodegeneration.