All Outputs (13)

Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation (2020)
Journal Article

The protein clusterin has been implicated in the molecular alterations that occur in articular cartilage during osteoarthritis (OA). Clusterin exists in two isoforms with opposing functions, and their roles in cartilage have not been explored. The se... Read More about Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation.

Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid (2018)
Journal Article

Bioreactor systems will likely play a key role in establishing regulatory compliant and cost-effective production systems for manufacturing engineered tissue grafts for clinical applications. However, the automation of bioreactor systems could become... Read More about Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid.

The effect of simvastatin on novel exploratory biomarkers of cartilage degradation (2018)
Presentation / Conference Contribution

There is emerging evidence of an association between osteoarthritis (OA) and atherosclerosis, with an underlying metabolic syndrome potentially driving the progression of both diseases. Proteomic analysis of OA synovial fluid, degenerative cartilage... Read More about The effect of simvastatin on novel exploratory biomarkers of cartilage degradation.

Aggrecanase degradation of type III collagen is associated with clinical knee pain (2018)
Journal Article

There is a lack of biochemical markers for non-invasive and objective assessment of symptomatic osteoarthritis (OA). Aggrecanase activity has been shown to be associated with joint deterioration and symptomatic disease through the degradation of extr... Read More about Aggrecanase degradation of type III collagen is associated with clinical knee pain.

Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines (2018)
Presentation / Conference Contribution

Chondrocytes rely primarily on glycolysis to meet their energy requirements, but possess the metabolic flexibility to support cell survival and matrix synthesis during periods of nutrient stress, by enhancing glycolysis with mitochondrial respiration... Read More about Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines.

Chondrocyte secretome: A source of novel insights and exploratory biomarkers of osteoarthritis (2017)
Journal Article

The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to r... Read More about Chondrocyte secretome: A source of novel insights and exploratory biomarkers of osteoarthritis.

Factors that influence cartilage implant integration during joint repair. (2016)
Journal Article

The low spontaneous healing capacity of articular cartilage, the avascular nature, and the acellularity of the interface of damaged cartilage, all these factors limit the integration between the implanted engineered cartilage and native articular car... Read More about Factors that influence cartilage implant integration during joint repair..

Lumican is a potential biomarker for osteoarthritis (2013)
Presentation / Conference Contribution

Purpose:
Fragmentation of small leucine rich proteoglycans (SLRPs), including decorin, biglycan, lumican, keratocan and fibromodulin, has been shown to occur in osteoarthritic articular cartilage (Melrose et al, 2008). The aim of this project was to... Read More about Lumican is a potential biomarker for osteoarthritis.

Expression of lumican in the synovial fluid of patients with osteoarthritis (OA) (2011)
Journal Article

Introduction Fragmentation of small leucine rich proteogly-
cans (SLRPs), including decorin, biglycan, lumican, keratocan
and fibromodulin, has been shown to occur in osteoarthritic
articular cartilage (Melrose et al. 2008). We have previously
sh... Read More about Expression of lumican in the synovial fluid of patients with osteoarthritis (OA).

Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression (2006)
Journal Article

We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of β-catenin. In this study we demonstrate directly that gr... Read More about Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression.

N-cadherin and b-catenin signalling regulates vascular smooth muscle cell proliferation and cell cycle genes (2006)
Journal Article

Vascular smooth muscle cell (VSMC) proliferation is a key event in the pathogenesis of vascular diseases. Dismantling of cadherin junctions and translocation of b-catenin to the cytoplasm occurs in proliferating VSMCs. To determine whether N-cadherin... Read More about N-cadherin and b-catenin signalling regulates vascular smooth muscle cell proliferation and cell cycle genes.

Cruciate ligament laxity and femoral intercondylar notch narrowing in early-stage knee osteoarthritis (2005)
Journal Article

Objective. The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture is known to cause secondary OA. Additionally, femoral notch narrowing at the anterior cruciate ligament (ACL) insertion... Read More about Cruciate ligament laxity and femoral intercondylar notch narrowing in early-stage knee osteoarthritis.

Fundamental subchondral bone changes in spontaneous knee osteoarthritis (2004)
Journal Article

Osteoarthritis has an unknown aetiology, and tissue samples from early stage human osteoarthritis tissue cannot be reliably obtained. Therefore understanding the development of OA relies on using animal models: such as the spontaneous changes seen in... Read More about Fundamental subchondral bone changes in spontaneous knee osteoarthritis.