Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines

Fellows, C.; Quasnichka, H.; Chowdhury, N.R.; Budd, E.; Skene, D.J.; Mobasheri, A.

doi:10.1016/j.joca.2018.02.373

All Outputs (4)

Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid (2018)
Journal Article

Bioreactor systems will likely play a key role in establishing regulatory compliant and cost-effective production systems for manufacturing engineered tissue grafts for clinical applications. However, the automation of bioreactor systems could become... Read More about Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid.

The effect of simvastatin on novel exploratory biomarkers of cartilage degradation (2018)
Presentation / Conference Contribution

There is emerging evidence of an association between osteoarthritis (OA) and atherosclerosis, with an underlying metabolic syndrome potentially driving the progression of both diseases. Proteomic analysis of OA synovial fluid, degenerative cartilage... Read More about The effect of simvastatin on novel exploratory biomarkers of cartilage degradation.

Aggrecanase degradation of type III collagen is associated with clinical knee pain (2018)
Journal Article

There is a lack of biochemical markers for non-invasive and objective assessment of symptomatic osteoarthritis (OA). Aggrecanase activity has been shown to be associated with joint deterioration and symptomatic disease through the degradation of extr... Read More about Aggrecanase degradation of type III collagen is associated with clinical knee pain.

Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines (2018)
Presentation / Conference Contribution

Chondrocytes rely primarily on glycolysis to meet their energy requirements, but possess the metabolic flexibility to support cell survival and matrix synthesis during periods of nutrient stress, by enhancing glycolysis with mitochondrial respiration... Read More about Metabolomics and metabolic function analysis of the secretome of articular cartilage and isolated chondrocytes in response to pro-inflammatory cytokines.