The efficacy and safety of PSD503 (phenylephrine 20%, w/w) for topical application in women with stress urinary incontinence. A phase II, multicentre, double-blind, placebo controlled, 2-way cross over study.

Robinson, Dudley; Abrams, Paul; Cardozo, Linda; Ellis-Jones, Julie; Heath, Pat; Wyllie, Mike

The efficacy and safety of PSD503 (phenylephrine 20%, w/w) for topical application in women with stress urinary incontinence. A phase II, multicentre, double-blind, placebo controlled, 2-way cross over study.

Robinson, Dudley; Abrams, Paul; Cardozo, Linda; Ellis-Jones, Julie; Heath, Pat; Wyllie, Mike

Authors

Dudley Robinson

Paul Abrams

Linda Cardozo

Julie Ellis-Jones

Pat Heath

Mike Wyllie

Abstract

This is the first proof of concept study to demonstrate that a topical α adrenergic agonist gel is rapidly and consistently absorbed vaginally and may have a role in the management of female SUI. However, since recruitment was difficult this may indicate that whilst objectively effective, acceptability in clinical practice may be poor.

Journal Article Type	Article
Publication Date	Dec 1, 2011
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Print ISSN	0301-2115
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	159
Issue	2
Pages	457-460
Keywords	stress urinary incontinence
Public URL	https://uwe-repository.worktribe.com/output/957321

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The efficacy and safety of PSD503 (phenylephrine 20%, w/w) for topical application in women with stress urinary incontinence. A phase II, multicentre, double-blind, placebo controlled, 2-way cross over study.

Robinson, Dudley; Abrams, Paul; Cardozo, Linda; Ellis-Jones, Julie; Heath, Pat; Wyllie, Mike

Authors

Abstract

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