The oncogene ERG: A key factor in prostate cancer

Adamo, P.; Ladomery, M. R.; Adamo, Patricia; Ladomery, Michael

Abstract

© 2016 Macmillan Publishers Limited All rights reserved. ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of transcription factors with roles in development that include vasculogenesis, angiogenesis, haematopoiesis and bone development. ERG's oncogenic potential is well known because of its involvement in Ewing's sarcoma and leukaemia. However, in the past decade ERG has become highly associated with prostate cancer development, particularly as a result of a gene fusion with the promoter region of the androgen-induced TMPRRSS2 gene. We review ERG's structure and function, and its role in prostate cancer. We discuss potential new therapies that are based on targeting ERG.

• Journal Article Type: Review
• Publication Date: Jan 28, 2016
• Journal: Oncogene
• Print ISSN: 0950-9232
• Publisher: Springer Nature [academic journals on nature.com]
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 4
• Pages: 403-414
• DOI: https://doi.org/10.1038/onc.2015.109
• Keywords: oncogene ERG, prostate cancer
• Public URL: https://uwe-repository.worktribe.com/output/912650
• Publisher URL: http://dx.doi.org/10.1038/onc.2015.109