Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?

Liverani, E; Paul, Carolyn

Abstract

Adrenomedullin is a vasodilatatory peptide, important during the inflammation process and also able to regulate blood-brain barrier function. Adrenomedullin and its receptors have been shown to be glucocorticoid-dependent in many cell types, including primary T cells and the major cellular components of the blood-brain barrier. Considering that the immunosuppressant, glucocorticoids are also well-known to regulate inflammation and blood-brain barrier properties, in this research highlight we review the evidence for glucocorticoid modulation of adrenomedullin secretion and adrenomedullin receptor expression at the glial/endothelial interface during physiological and inflammatory conditions. This view would offer a platform for consideration of new therapeutic options aiming to restore or maintain the blood brain barrier.

• Journal Article Type: Article
• Acceptance Date: Dec 20, 2013
• Publication Date: Jan 1, 2014
• Publicly Available Date: Jun 6, 2019
• Journal: Receptors and Clinical Investigation
• Print ISSN: 2330-0558
• Publisher: Smart Science and Technology
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 1
• DOI: https://doi.org/10.14800/rci.25
• Keywords: adrenomedullin, glucocorticoids, blood-brain barrier, RAMPs
• Public URL: https://uwe-repository.worktribe.com/output/825419
• Publisher URL: http://dx.doi.org/10.14800/rci.25