Propofol detection for monitoring of intravenous anaesthesia: A review

Ferrier, David; Kiely, Janice; Luxton, Richard

Abstract

This paper presents a review of established and emerging methods for detecting and quantifying the intravenous anaesthetic propofol in solution. There is growing evidence of numerous advantages of total intravenous anaesthesia using propofol compared to conventional volatile-based anaesthesia, both in terms of patient outcomes and environmental impact. However, volatile-based anaesthesia still accounts for the vast majority of administered general anaesthetics, largely due to a lack of techniques for real-time monitoring of patient blood propofol concentration. Herein, propofol detection techniques that have been developed to date are reviewed alongside a discussion of remaining challenges.

• Journal Article Type: Review
• Acceptance Date: Jun 28, 2021
• Online Publication Date: Jul 2, 2021
• Publication Date: 2022-06
• Deposit Date: Jul 2, 2021
• Publicly Available Date: Jun 10, 2022
• Journal: Journal of Clinical Monitoring and Computing
• Print ISSN: 1387-1307
• Electronic ISSN: 1573-2614
• Publisher: Springer (part of Springer Nature)
• Peer Reviewed: Peer Reviewed
• Volume: 36
• Pages: 315-323
• DOI: https://doi.org/10.1007/s10877-021-00738-5
• Keywords: Propofol; 2,6-Diisopropylphenol; Real-time monitoring; Optical detection; Electrochemical detection
• Public URL: https://uwe-repository.worktribe.com/output/7503557
• Publisher URL: https://link.springer.com/article/10.1007/s10877-021-00738-5