Recording and reporting of ultra-high dose rate “FLASH” delivery for preclinical and clinical settings

Tobias Böhlen, Till; Psoroulas, Serena; Aylward, Jack D; Beddar, Sam; Douralis, Alexandros; Delpon, Grégory; Garibaldi, Cristina; Gasparini, Alessia; Schüler, Emil; Stephan, Frank; Moeckli, Raphaël; Subiel, Anna

Abstract

Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic index of radiation therapy (RT) by sparing normal tissues compared to conventional dose rate irradiations. Insufficient and inconsistent reporting in physics and dosimetry of preclinical and translational studies may have contributed to a reproducibility crisis of radiobiological data in the field. Consequently, the development of a common terminology, as well as common recording, reporting, dosimetry, and metrology standards is required. In the context of UHDR irradiations, the temporal dose delivery parameters are of importance, and under-reporting of these parameters is also a concern.This work proposes a standardization of terminology, recording, and reporting to enhance comparability of both preclinical and clinical UHDR studies and and to allow retrospective analyses to aid the understanding of the conditions which give rise to the FLASH effect.

• Journal Article Type: Article
• Acceptance Date: Aug 19, 2024
• Online Publication Date: Sep 6, 2024
• Publication Date: 2024-11
• Deposit Date: Sep 19, 2024
• Publicly Available Date: Sep 7, 2025
• Journal: Radiotherapy and Oncology
• Print ISSN: 0167-8140
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 200
• Article Number: 110507
• DOI: https://doi.org/10.1016/j.radonc.2024.110507
• Public URL: https://uwe-repository.worktribe.com/output/12898098