Masking of messenger RNA by Y-box proteins

Sommerville, John; Ladomery, Michael

Abstract

The Y-box proteins are defined by their ability to bind to Y-box promoter elements and to help regulate transcription of a wide variety of genes. However, Y-box proteins are also identified as abundant proteins in the cytoplasm of germ cells, where they are found bound to stored mRNA molecules. Binding of Y-box proteins to mRNA sequences, both in vitro and in vivo, has been shown to effect their translational repression ("masking"). Here we discuss the ability of Y box proteins to recognize different nucleic acid structures and to become involved in regulation of both transcription and translation.

• Journal Article Type: Article
• Publication Date: Jan 1, 1996
• Journal: The FASEB Journal
• Print ISSN: 0892-6638
• Electronic ISSN: 1530-6860
• Publisher: Federation of American Society of Experimental Biology
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Pages: 435-443
• Public URL: https://uwe-repository.worktribe.com/output/1106228
• Publisher URL: http://www.fasebj.org/cgi/content/abstract/10/4/435