Outputs (362)

The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase (2019)
Journal Article

Naematolin is a biologically active sesquiterpene produced by Hypholoma species. Low titres and complex structure constrain the exploitation of this secondary metabolite. Here, we de novo sequenced the H. fasciculare genome to identify a candidate bi... Read More about The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase.

Global food safety as a complex adaptive system: Key concepts and future prospects (2019)
Journal Article

Background
Over the last few decades the food production, distribution and consumption chains have become complex as a result of globalisation and food travelling over large distances. The food supply chain is a multi-layered structure with multiple... Read More about Global food safety as a complex adaptive system: Key concepts and future prospects.

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase (2019)
Journal Article

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by ho... Read More about Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase.

Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease (2019)
Journal Article

The fungus Lecanicillium fungicola causes dry bubble disease in the white button mushroom Agaricus bisporus. Control strategies are limited, as both the host and pathogen are fungi, and there is limited understanding of the interactions in this patho... Read More about Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease.

Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours (2019)
Journal Article

Tumours defective in the DNA homologous recombination repair pathway can be effectively treated with poly (ADP-ribose) polymerase (PARP) inhibitors; these have proven effective in clinical trials in patients with BRCA gene function-defective cancers.... Read More about Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity (2019)
Journal Article

Three new polyketide-derived natural products, cladobotric acids G-I (1-3), and six known metabolites (4, 5, 8-11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spectroscop... Read More about Cladobotric acids: Metabolites from cultures of Cladobotryum sp., Semisynthetic analogues and antibacterial activity.

Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi (2018)
Journal Article

Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crysta... Read More about Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi.

Non-muscle myosin ii drives vesicle loss during human reticulocyte maturation (2018)
Journal Article

The process of maturation of reticulocytes into fully mature erythrocytes that occurs in the circulation is known to be characterized by a complex interplay between loss of cell surface area and volume, removal of remnant cell organelles and redundan... Read More about Non-muscle myosin ii drives vesicle loss during human reticulocyte maturation.

Food safety culture - the food inspectors' perspective (2018)
Journal Article

Purpose
The purpose of this paper is to discuss the challenges for food inspectors when attempting to assess the food safety culture of a business. It is the eighth article in this issue of Worldwide Hospitality and Tourism Themes, discussing the im... Read More about Food safety culture - the food inspectors' perspective.

Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing (2018)
Journal Article

Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor b... Read More about Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.