Outputs (362)

Allium cepa remediates oxidative stress-mediated hepatic DNA damage in cadmium-exposed rats through enhanced p53 expression and inhibition of bcl2 (2020)
Journal Article

BACKGROUND:
Cadmium (Cd), a naturally occurring toxic metal, in addition to being cytotoxic, has been shown to be responsible for inducing free radical-dependent DNA damage in cells. Allium cepa is also known to ameliorate cadmium sulphate-induced... Read More about Allium cepa remediates oxidative stress-mediated hepatic DNA damage in cadmium-exposed rats through enhanced p53 expression and inhibition of bcl2.

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis (2020)
Journal Article

Dehydrated hereditary stomatocytosis 1 or hereditary xerocytosis (HX, OMIM 194380) is a rare hereditary autosomal dominant disorder characterized by hemolytic anemia and red blood cell (RBC) dehydration. The occurrence of HX is linked with gain-of-fu... Read More about PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis.

Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation (2020)
Journal Article

The effects of ionising radiation (IR) on plants are important for environmental protection but also in agriculture, horticulture, space science, and plant stress biology. Much current understanding of the effects of IR on plants derives from acute h... Read More about Developmental, morphological and physiological traits in plants exposed for five generations to chronic low-level ionising radiation.

A grain rot of rice in Iran caused by a Xanthomonas strain closely related to X. sacchari (2020)
Journal Article

Rice grain rot disease was detected for the first time in Mazandaran Province, Iran. The bacteria isolated from infected rice plants showed grains rotted and darkening. A Xanthomonas strain closely connected to X. sacchari was identified using molecu... Read More about A grain rot of rice in Iran caused by a Xanthomonas strain closely related to X. sacchari.

Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42 (2020)
Journal Article

A key challenge in the implementation of anti-metastatics as cancer therapies is the multi-modal nature of cell migration, which allows tumour cells to evade the targeted inhibition of specific cell motility pathways. The nuclear factor-kappaB (NF-κB... Read More about Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42.

Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire (2019)
Journal Article

Chimpanzees are well-known tool users, with differences reported in the tool use repertoires among communities and subspecies. Chimpanzees at most study sites exhibit some degree of stick tool use behaviour for extractive foraging, with the exception... Read More about Stick tool use by chimpanzees in a forest fragment in Uganda’s Budongo-Bugoma corridor: Preliminary observations from Kasongoire.

Reticulocyte and red blood cell deformation triggers specific phosphorylation events (2019)
Journal Article

The capacity to undergo substantial deformation is a defining characteristic of the red blood cell (RBC), facilitating transit through the splenic interendothelial slits and microvasculature. Establishment of this remarkable property occurs during a... Read More about Reticulocyte and red blood cell deformation triggers specific phosphorylation events.

Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies (2019)
Journal Article

Objectives: Bioreactor-based production systems have the potential to overcome limitations associated with conventional tissue engineering manufacturing methods, facilitating regulatory compliant and cost-effective production of engineered grafts for... Read More about Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies.

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements (2019)
Journal Article

Investigating the role that host erythrocyte proteins play in malaria infection is hampered by the genetic intractability of this anucleate cell. Here we report that reticulocytes derived through in vitro differentiation of an enucleation-competent i... Read More about Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.

Human factors and ergonomics systems-based tools for understanding and addressing global problems of the twenty-first century (2019)
Journal Article

Sustainability is a systems problem with humans as integral elements of the system. However, sustainability problems usually have a broader scope than socio-technical systems and therefore, require additional considerations. This requires a fuller in... Read More about Human factors and ergonomics systems-based tools for understanding and addressing global problems of the twenty-first century.