Outputs (1317)

Considerations of the importance of redox state for reactive nitrogen species action (2019)
Journal Article

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not... Read More about Considerations of the importance of redox state for reactive nitrogen species action.

Protein SUMOylation regulates insulin secretion at multiple stages (2019)
Journal Article

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the... Read More about Protein SUMOylation regulates insulin secretion at multiple stages.

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo (2018)
Journal Article

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. N-nitroso compounds are alkylating agents, which are widespread in our diet and the environment. They induce DNA alkylation adducts such as O 6 -methylguanine (O 6 -MeG), which is repair... Read More about Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo.

An evidence-based approach to specifying survey effort in ecological assessments of bat activity (2019)
Journal Article

Robust ecological assessments are fundamental for effective wildlife conservation. Owing to the high legal protection of bats, surveys are frequently required as part of ecological assessments. Yet there is uncertainty about the amount of survey effo... Read More about An evidence-based approach to specifying survey effort in ecological assessments of bat activity.

Hydrophilic interaction liquid chromatography: An update (2019)
Journal Article

This article is an update on the technique of hydrophilic interaction liquid chromatography (HILIC) and covers recent ideas on the mechanism of separation, and how it may be manipulated to suit the separation of particular sample types. The advantage... Read More about Hydrophilic interaction liquid chromatography: An update.

Comparison of trihalomethane formation using chlorine-based disinfectants within a model system; Applications within point-of-use drinking water treatment (2019)
Journal Article

© 2019 Clayton, Thorn and Reynolds. Point-of-use (POU) drinking water treatment systems provide solutions for communities where centralized facilities are unavailable. Effective POU systems treat and reduce the number of pathogens in POU water suppl... Read More about Comparison of trihalomethane formation using chlorine-based disinfectants within a model system; Applications within point-of-use drinking water treatment.

Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice (2019)
Journal Article

© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and purpose: PDE inhibitors such as sildenafil alleviate lower urinary tract symptoms; however, a comple... Read More about Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.

First confirmed record of suni (Neotragus moschatus) and rusty-spotted genet (Genetta maculata) in Nyika National Park, Malawi (2019)
Journal Article

Conservation of National Parks depends on accurate measurements of biodiversity, and therefore keeping an accurate list of species is key to determining biodiversity loss or gain in an ecosystem. This study confirms the presence of two disputed speci... Read More about First confirmed record of suni (Neotragus moschatus) and rusty-spotted genet (Genetta maculata) in Nyika National Park, Malawi.

The potential role of the hedgehog signalling pathway in the regulation of epithelial-mesenchymal transition in breast cancer
Thesis

Breast cancer is a deadly disease that accounts for a third of all female cancer- related deaths globally. Although recent advances in early diagnosis and targeted therapy using prognostic markers have reduced deaths, more than 50% of newly diagnosed... Read More about The potential role of the hedgehog signalling pathway in the regulation of epithelial-mesenchymal transition in breast cancer.

661W photoreceptor cell line as a cell model for studying retinal ciliopathies (2019)
Journal Article

Copyright © 2019 Wheway, Nazlamova, Turner and Cross. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the ori... Read More about 661W photoreceptor cell line as a cell model for studying retinal ciliopathies.

Network theory and the resilience of redox signaling (2019)
Journal Article

The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to... Read More about Network theory and the resilience of redox signaling.

The role of redox in signal transduction (2019)
Book Chapter

© Springer Science+Business Media, LLC, part of Springer Nature 2019. It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and pla... Read More about The role of redox in signal transduction.

Equations to support redox experimentation (2019)
Book Chapter

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Working with redox compounds needs to take into account the oxidation and reduction state of the compound under study. This redox state can be influenced by the media in which the... Read More about Equations to support redox experimentation.

Hydrogen sulfide and environmental stresses (2018)
Journal Article

© 2018 Elsevier B.V. Hydrogen sulfide (H 2 S) is part of a suite of small reactive molecules which are known to be involved in cell signaling events in plants. It is produced by cells, can move around, including through membranes, and can be removed... Read More about Hydrogen sulfide and environmental stresses.

Methods for the addition of redox compounds (2019)
Book Chapter

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Often in redox biology experiments there is a need to add compounds which impinge on the redox of the cellular environment cell. Such compounds may include reactive oxygen species... Read More about Methods for the addition of redox compounds.

Investigating ROS, RNS, and H2S-sensitive signaling proteins (2019)
Book Chapter

© Springer Science+Business Media, LLC, part of Springer Nature 2019. The modification of proteins is a key way to alter their activity and function. Often thiols, cysteine residues, on proteins are attractive targets for such modification. Assuming... Read More about Investigating ROS, RNS, and H2S-sensitive signaling proteins.

A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes (2015)
Journal Article

Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe the first whole genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining... Read More about A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes.

796 Expression of aquaporin channels in pig urinary bladder (2015)
Journal Article

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes (2015)
Journal Article

© 2015 Macmillan Publishers Limited. Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of... Read More about An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks (2019)
Journal Article

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Microbiomes from every environment contain a myriad of uncultivated archaeal and bacterial viruses, but studying these viruses is hampered by the lack of a universal, sca... Read More about Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks.