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Considerations of the importance of redox state for reactive nitrogen species action

Hancock, John T.

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John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling



Abstract

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not always easy to understand. Here, some of the issues that should be considered are discussed. This includes how NO may interact directly with other reactive signals, such as reactive oxygen and sulfur species, how NO metabolism is almost certainly compartmentalised, that threshold levels of RNS may need to be reached to have effects and how the intracellular redox environment may impact on NO signalling. Until better tools are available to understand how NO is generated in cells, where it accumulates and to what levels it reaches, it will be hard to get a full understanding of NO signalling. The interaction of RNS metabolism with the intracellular redox environment needs further investigation. A changing redox poise will impact on whether RNS species can thrive in or around cells. Such mechanisms will determine whether specific RNS can indeed control the responses needed by a cell.

Citation

Hancock, J. T. (2019). Considerations of the importance of redox state for reactive nitrogen species action. Journal of Experimental Botany, 70(17), 4323-4331. https://doi.org/10.1093/jxb/erz067

Journal Article Type Article
Acceptance Date Feb 6, 2019
Online Publication Date Feb 22, 2019
Publication Date Sep 1, 2019
Deposit Date Feb 11, 2019
Publicly Available Date Feb 23, 2020
Journal Journal of Experimental Botany
Print ISSN 0022-0957
Electronic ISSN 1460-2431
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 70
Issue 17
Pages 4323-4331
DOI https://doi.org/10.1093/jxb/erz067
Keywords nitric oxide, reactive oxygen species, hydrogen sulfide, compartmentalisation, thresholds
Public URL https://uwe-repository.worktribe.com/output/851852
Publisher URL https://doi.org/10.1093/jxb/erz067

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Copyright Statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Experimental Botany following peer review. The version of record [Hancock, J. (2019) Considerations of the importance of redox state on reactive nitrogen species action. Journal of Experimental Botany. ISSN 0022-0957] is available online at: https://doi.org/10.1093/jxb/erz067.


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Licence
http://www.rioxx.net/licenses/all-rights-reserved

Copyright Statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Experimental Botany following peer review. The version of record [Hancock, J. (2019) Considerations of the importance of redox state on reactive nitrogen species action. Journal of Experimental Botany. ISSN 0022-0957] is available online at: https://doi.org/10.1093/jxb/erz067.







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