Considerations of the importance of redox state for reactive nitrogen species action

Hancock, John T.

Abstract

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not always easy to understand. Here, some of the issues that should be considered are discussed. This includes how NO may interact directly with other reactive signals, such as reactive oxygen and sulfur species, how NO metabolism is almost certainly compartmentalised, that threshold levels of RNS may need to be reached to have effects and how the intracellular redox environment may impact on NO signalling. Until better tools are available to understand how NO is generated in cells, where it accumulates and to what levels it reaches, it will be hard to get a full understanding of NO signalling. The interaction of RNS metabolism with the intracellular redox environment needs further investigation. A changing redox poise will impact on whether RNS species can thrive in or around cells. Such mechanisms will determine whether specific RNS can indeed control the responses needed by a cell.

• Journal Article Type: Article
• Acceptance Date: Feb 6, 2019
• Online Publication Date: Feb 22, 2019
• Publication Date: Sep 1, 2019
• Deposit Date: Feb 11, 2019
• Publicly Available Date: Feb 23, 2020
• Journal: Journal of Experimental Botany
• Print ISSN: 0022-0957
• Electronic ISSN: 1460-2431
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 70
• Issue: 17
• Pages: 4323-4331
• DOI: https://doi.org/10.1093/jxb/erz067
• Keywords: nitric oxide, reactive oxygen species, hydrogen sulfide, compartmentalisation, thresholds
• Public URL: https://uwe-repository.worktribe.com/output/851852
• Publisher URL: https://doi.org/10.1093/jxb/erz067
• Contract Date: Feb 11, 2019